基于数据挖掘分析针药结合治疗腹泻型肠易激综合征的临床优势和选穴规律OA
Exploring the clinical advantages and rules of acupoint selection with the integration of acupuncture and medication in treating irritable bowel syndrome with diarrhea based on data mining
目的 利用数据挖掘技术,探讨针药结合治疗腹泻型肠易激综合征(IBS-D)的临床优势、结合方式、选穴归经规律以及核心处方,以期为临床实践提供针药结合相关依据和使用策略.方法 系统检索荷兰医学文摘(Embase)、Ovid公司医学期刊全文数据库(Ovid)、美国生物医学信息检索系统(PubMed)、核心合集数据库(Web of Science)、中国知网(CNKI)、万方学术期刊全文数据库(Wan Fang)、维普资讯中文期刊服务平台(VIP)、中国生物医学文献服务系统(SinoMed)等数据库 2004 年 1 月 1 日至 2025 年 5 月31 日针药结合治疗IBS-D的临床研究文献并筛选.采用频数统计法分析临床优势及腧穴使用频次,通过SPSS Modeler 18.0 进行关联规则分析、SPSS Statistics 27.0 进行聚类分析,并利用Gephi 0.10 构建复杂网络模型,筛选核心腧穴及配伍规律.结果 共纳入 83 篇文献.针药结合在改善IBS-D临床症状和体征、脑肠肽水平和调节情绪方面优势显著.纳入处方涉及穴位 40 个,总频次 536 次,使用频次排名前 3 位的穴位为天枢、足三里和太冲,使用频次最高的经脉为足阳明胃经,核心穴位组合为天枢-足三里,特定穴中五输穴应用频次最高.聚类分析得到 4 个有效聚类群.复杂网络分析显示,核心腧穴群分为两类:社团 1侧重"调肠-调神",社团 2 体现"前后配穴".结论 针药结合通过多靶点调控脑肠轴,改善IBS-D胃肠功能及情绪障碍,临床优势显著.未来需加强针药协同机制及辨证分型研究,以深化治疗方案的科学性与个体化.
Objective To investigate the clinical advantages,combination approaches,acupoint selection and meridian affiliation patterns,and core prescriptions of acupuncture combined with medication for irritable bowel syndrome with diarrhea(IBS-D)using data mining technology,with the aim of providing evidence-based rationale and application strategies for this integrated approach in clinical practice.Methods A systematic search was conducted for clinical research literature on acupuncture-medication combination therapy for IBS-D published from January 1,2004,to May 31,2025,in the following databases:Embase,Ovid,PubMed,Web of Science,CNKI,WanFang,VIP,and SinoMed.Retrieved studies were screened for inclusion.Frequency statistics were employed to analyze clinical advantages and acupoint usage frequency.Association rule analysis was performed using SPSS Modeler 18.0,cluster analysis using SPSS Statistics 27.0,and a complex network model was constructed using Gephi 0.10 to identify core acupoints and compatibility patterns.Results A total of 83 articles were included.The combination of acupuncture and medication demonstrated significant advantages in improving IBS-D clinical symptoms and signs,modulating brain-gut peptide levels,and regulating mood disorders.The included prescriptions involved 40 acupoints with a total application frequency of 536 times.The top three most frequently used acupoints were Tianshu(ST 25),Zusanli(ST 36),and Taichong(LR 3).The Stomach Meridian of Foot-Yangming was the most frequently utilized meridian.The core acupoint combination identified was Tianshu(ST 25)-Zusanli(ST 36).Among the specific acupoint categories,the Five-Shu points had the highest application frequency.Cluster analysis yielded four effective clusters.Complex network analysis revealed that the core acupoints could be categorized into two clusters:Cluster 1 emphasized intestinal regulation and mind regulation,while Cluster 2 reflected the anterior-posterior acupoint pairing principle.Conclusion Acupuncture combined with medication significantly improves gastrointestinal function and alleviates emotional disturbances in IBS-D patients through multi-target regulation of the brain-gut axis,demonstrating clear clinical advantages.Future research should focus on elucidating the synergistic mechanisms of acupuncture and medication and refining syndrome differentiation models to enhance the scientific rigor and personalization of treatment protocols.
王婧瞳;李荣喆;李崟嘉;李玉萍;徐媛
天津中医药大学针灸推拿学院,天津 301617天津中医药大学针灸推拿学院,天津 301617天津中医药大学针灸推拿学院,天津 301617天津中医药大学针灸推拿学院,天津 301617国家中医针灸临床医学研究中心,天津 300193
医药卫生
腹泻型肠易激综合征针药结合数据挖掘临床优势选穴规律
Irritable bowel syndrome with diarrheaCombination of acupuncture and medicineData miningClinical advantagesRules of acupoint selection
《中国医药科学》 2025 (24)
10-16,7
国家重点研发计划(2024YFC3505205).
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