基于信息生态理论的数字化药物警戒生态体系构建研究OA

Objective To construct a digital pharmacovigilance ecosystem based on information ecology theory.Methods Relevant literatures on digital pharmacovigilance were retrieved from CNKI,PubMed,and EBSCO databases,The application paths for artificial intelligence,large language models,digital twins,big data,and cloud computing in pharmacovigilance were proposed,and summarized the advanced experiences of digital technology application in pharmacovigilance in foreign countries.Results and Conclusion Various digital technologies such as artificial intelligence and digital twins are developing rapidly and have become a key driving force for the reform of the pharmacovigilance system.By empowering all links of pharmacovigilance,digital technologies have significantly improved the efficiency and accuracy of drug safety monitoring,providing strong support for the efficient implementation of pharmacovigilance.From the perspective of information ecology theory,a digital pharmacovigilance ecosystem with four core elements:pharmacovigilance information platform,digital technology,responsible subject,and social environment are constructed.The information chain is used to connect the industrial chain,risk chain,and responsibility chain,which can enhance the predictability,targeting,and timeliness of pharmacovigilance,improve the efficiency and quality of pharmacovigilance management,and ensure the safety of patients'medication use.