小胶质细胞在癫痫发生中作用的研究进展OA

In recent years,an increasing number of scholars have explored the relationship between microglia and epilepsy,discovering that neuroinflammation mediated by microglia through polarization and phagocytosis,oxidative stress,destruc-tion of the blood-brain barrier,neurogenesis,etc.are closely related to the onset of epilepsy.Numerous studies have found that microglia play a bidirectional regulatory role in the occur-rence of epilepsy,which is mainly related to their phenotypes and polarization.Taking microglia and the onset of epilepsy as the starting point,this paper reviews the role of microglia polar-ization and phagocytosis-mediated neuroinflammation in epilep-tic seizures in recent years,aiming to provide new ideas and tar-gets for the clinical prevention and treatment of epilepsy.