淋巴细胞相关炎症指数在甲状腺乳头状癌淋巴结转移中的研究进展OA

In recent years,the interplay between inflammation and tumors has become a research focus,particularly offering new perspectives for predicting lymph node metastasis(LNM)in patients with papillary thyroid carcinoma(PTC).This review systematically summarized the molecular mechanisms linking neutrophil-to-lymphocyte ratio(NLR),lymphocyte-to-monocyte ratio(LMR),platelet-to-lymphocyte ratio(PLR),and systemic immune-inflammation index(SII)with tumor cells.It revealed that SII accurately reflects the entire tumor immune response by integrating platelet-mediated angiogenesis,neutrophil-driven inflammatory cascades,and dynamic lymphocyte depletion.Moreover,a preoperative decision tree model based on these inflammatory indices improved the positive rate of central lymph node dissection,providing a theoretical basis for precise risk stratification and optimization of individualized treatment strategies for PTC patients with LNM.