血府逐瘀汤辅助金蝉止痒胶囊治疗消渴病伴皮肤瘙痒湿热血瘀证临床研究OA
Clinical Study on Xuefu Zhuyu Decoction as Adjuvant Therapy of Jinchan Zhiyang Capsules for Wasting-Thirst Complicated by Skin Itching with Syndrome of Damp-Heat and Blood Stasis
目的:观察血府逐瘀汤辅助金蝉止痒胶囊治疗消渴病伴皮肤瘙痒湿热血瘀证的临床疗效.方法:选取2022年1月—2024年12月开封市中医院收治的102例消渴病伴皮肤瘙痒患者,按随机数字表法分为对照组和研究组各51例.2组均行常规降糖治疗,对照组给予金蝉止痒胶囊口服,研究组在对照组基础上加用血府逐瘀汤辅助治疗.评价 2 组临床疗效,比较 2 组中医证候积分、血糖水平[空腹血糖(FBG)、餐后 2 h血糖(P2hBG)]、皮肤瘙痒程度[视觉模拟评分法(VAS)]及不良反应发生情况.结果:研究组总有效率为94.12%(48/51),高于对照组78.43%(40/51)(P＜0.05).治疗后,2组中医证候主症积分、次症积分及总积分均较治疗前降低(P＜0.05),且研究组中医证候主症积分、次症积分及总积分均低于对照组(P＜0.05).治疗后,2组FBG、P2hBG水平均较治疗前降低(P＜0.05),且研究组FBG、P2hBG水平均低于对照组(P＜0.05).治疗后,2组VAS评分较治疗前降低(P＜0.05),且研究组VAS评分低于对照组(P＜0.05).研究组不良反应发生率为9.80%(5/51),低于对照组25.49%(13/51)(P＜0.05).结论:血府逐瘀汤辅助金蝉止痒胶囊治疗消渴病伴皮肤瘙痒湿热血瘀证患者可提高临床疗效,改善其中医证候,控制血糖水平,减轻皮肤瘙痒情况,且安全性高.
Objective:To observe the clinical effect of Xuefu Zhuyu Decoction as adjuvant therapy of Jinchan Zhiyang Capsules on wasting-thirst complicated by skin itching with syndrome of damp-heat and blood stasis.Methods:A total of 102 patients with wasting-thirst complicated by skin itching were selected from Kaifeng Hospital of Traditional Chinese Medicine from January 2022 to December 2024,and they were divided into the control group and the study group according to the random number table method,with 51 cases in each group.Both groups were treated with routine hypoglycemic therapy.The control group was additionally given Jinchan Zhiyang Capsules,and the study group was additionally treated with Xuefu Zhuyu Decoction based on the treatment in the control group.The clinical effects in the two groups were evaluated,and the traditional Chinese medicine syndrome scores,blood glucose levels[fasting blood glucose(FBG)and 2-hour postprandial blood glucose(P2hBG)],severity of skin itching[Visual Analogue Scale(VAS)],and the incidence of adverse reactions were compared between the two groups.Results:The total effective rate was 94.12%(48/51)in the study group,higher than that of 78.43%(40/51)in the control group(P＜0.05).After treatment,the scores of main symptoms,secondary symptoms and total scores of traditional Chinese medicine syndromes in the two groups were decreased when compared with those before treatment(P＜0.05),and the above scores in the study group were lower than those in the control group(P＜0.05).After treatment,the levels of FBG and P2hBG in the two groups were down-regulated when compared with those before treatment(P＜0.05),and the levels of FBG and P2hBG in the study group were lower than those in the control group(P＜0.05).After treatment,the VAS scores in the two groups were reduced when compared with those before treatment(P＜0.05),and the VAS score in the study group was lower than that in the control group(P＜0.05).The incidence of adverse reactions was 9.80%(5/51)in the study group,lower than that of 25.49%(13/51)in the control group(P＜0.05).Conclusion:Xuefu Zhuyu Decoction as adjuvant therapy of Jinchan Zhiyang Capsules can enhance the clinical effect on patients with wasting-thirst complicated by skin itching with syndrome of damp-heat and blood stasis,which can improve the traditional Chinese medicine syndromes,control the level of blood glucose and reduce the skin itching with great safety.
米宜静;米柏岳;刘姗姗
开封市中医院皮肤科,河南 开封 475000襄城县中医院国医堂,河南 襄城 461700开封市中医院皮肤科,河南 开封 475000
医药卫生
消渴病皮肤瘙痒湿热血瘀证血府逐瘀汤金蝉止痒胶囊中医证候积分视觉模拟评分法
Wasting-thirstSkin itchingSyndrome of damp-heat and blood stasisXuefu Zhuyu DecoctionJinchan Zhiyang CapsulesTraditional Chinese medicine syndrome scoresVisual Analogue Scale
《新中医》 2026 (1)
37-41,5
河南医学科技攻关计划联合共建项目(LHGJ20201154)
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