姜黄素微藻载运体系的构建及评价OA

Microalgae(MA)as a kind of self-sustaining autotrophic organism with rich nutri-tion and high photosynthetic utilization rate,has a promising development prospect in food,medicine,and genetic engineering fields.Curcumin(Cur)is a natural monomer extracted from turmeric rhizomes,which has various biological activities such as antioxidation,anti-in-flammation,anti-tumor,protection of kidneys and liver,etc.However,its solubility is ex-tremely poor and its bioavailability is relatively low.In this experiment,microalgae was used as the delivery carrier,and Curcumin microalgae delivery system(MA@Cur)was prepared by solvent evaporation method.The loading performance,release behavior,cellular uptake,gastrointestinal distribution and antioxidant activity of this system were evaluated.The re-sults showed that MA@Cur had a high loading rate and good stability,which could signifi-cantly improve the water dispersibility and intestinal fluid release degree of Cur;Cell experi-ments indicated that this system had good biocompatibility and could significantly promote the uptake of Cur by intestinal cells,effectively enhancing the antioxidant activity of Cur;The in vivo distribution experiments in mice showed that MA@Cur could prolong the retention time of active molecules in the intestinal tract.In conclusion,microalgae as the delivery carri-er of Curcumin can significantly enhance the solubility,stability and oral absorption efficiency of Curcumin,providing a reference for the efficient delivery of hydrophobic active molecules in vivo and in vitro.