基于"脾主升清"探讨肠道菌群在针刺治疗卒中后抑郁的作用OA
Role of Gut Microbiota in Acupuncture Treatment of Post-stroke Depression Based on Spleen Governing Ascending Clear
卒中后抑郁(post-stroke depression,PSD)是一种常见的脑卒中并发症,严重影响患者的生活质量和康复进程,其属于中医学"郁证"范畴.脾气亏虚、升输无力是本病的病机关键.中医理论中的"脾"与现代医学的肠道菌群在经络联系、生理功能及病理表现方面具有相关性.大量研究表明肠道菌群与PSD的发病与治疗密切相关,肠道菌群可被看作针刺治疗PSD的一个作用靶点.基于此,针刺治疗以调脾为原则,通过健脾益气调节肠道菌群结构,从而改善抑郁症状,为治疗PSD提供新视角.
Post-stroke depression(PSD)is a common complication of stroke,which seriously affects the quality of life and rehabili-tation process of patients.It belongs to the category of depression syndrome in traditional Chinese medicine.Deficiency of spleen qi and weakness of ascending and descending are the key pathogenesis of this disease.The spleen in the theory of traditional Chinese medicine is related to the intestinal flora of modern medicine in terms of meridian connection,physiological function and pathological manifesta-tions.A large number of studies have shown that intestinal flora is closely related to the pathogenesis and treatment of PSD,and intesti-nal flora can be regarded as a target for acupuncture treatment of PSD.Based on this,acupuncture treatment is based on the principle of regulating the spleen,and regulates the structure of intestinal flora by restoring the spleen and ascending the clear,so as to improve the symptoms of depression and provide a new perspective for the treatment of PSD.
周合馨;肖洪波;邹丽
安徽中医药大学第一临床医学院,安徽 合肥 230021安徽中医药大学第一附属医院针灸康复一科,安徽 合肥 230031安徽中医药大学第一临床医学院,安徽 合肥 230021
医药卫生
卒中后抑郁脾主升清脾气亏虚针刺肠道菌群
post-stroke depressionspleen governing ascending clearspleen deficiencyacupuncturegut microbiota
《陕西中医药大学学报》 2026 (1)
35-39,5
安徽省临床医学研究转化专项(202304295107020101)
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