肝移植受者肌肉脂肪变性的研究进展OA
Research progress on myosteatosis in liver transplant recipients
肌肉脂肪变性是终末期肝病患者常见的并发症之一,与肝移植术后的不良结局显著相关.目前肌肉脂肪变性的诊断标准尚未建立,其中最常用的诊断方法是CT.肌肉脂肪变性的发生机制是多因素的,而将其与终末期肝病联系起来的病理生理机制仍不完全清楚.越来越多学者认识到肌肉脂肪变性的严重程度和临床后果密切相关,但尚无有效的治疗选择.本文就肌肉脂肪变性的病理生理学机制、诊断方法及其对肝移植受者预后的影响进行综述,并探讨当前的治疗策略,为肝移植受者围手术期管理提供参考.
Myosteatosis is one of the common complications in patients with end-stage liver disease,which is significantly associated with poor outcomes after liver transplantation.Currently,diagnostic criteria of myosteatosis have not been established,and CT is the most commonly used for diagnosis.The pathogenesis of myosteatosis is multifactorial,and the pathophysiological mechanisms linking it to end-stage liver disease are not fully understood.An increasing number of scholars have recognized that the severity of myosteatosis is closely related to its clinical consequences,but there are no effective treatment options available.This article reviews the pathophysiological mechanisms and diagnostic methods of myosteatosis,and its impact on the prognosis of liver transplant recipients,and discusses current treatment strategies to provide references for the perioperative management of liver transplant recipients.
蔡俊锋;贺敬东;姜雨欣;许磊波
510289 广州,中山大学孙逸仙纪念医院胆胰外科暨肝移植科510289 广州,中山大学孙逸仙纪念医院胆胰外科暨肝移植科510289 广州,中山大学孙逸仙纪念医院胆胰外科暨肝移植科510289 广州,中山大学孙逸仙纪念医院胆胰外科暨肝移植科
医药卫生
肝移植肌肉脂肪变性终末期肝病胰岛素抵抗肌肉减少症骨骼肌放射密度线粒体功能障碍
Liver transplantationMyosteatosisEnd-stage liver diseaseInsulin resistanceSarcopeniaSkeletal muscle radiodensityMitochondrial dysfunction
《器官移植》 2026 (1)
61-67,7
国家自然科学基金(82173229)中山大学孙逸仙纪念医院"逸仙科研启航项目"(SYSQH-II-2024-05)
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