肝素结合蛋白在器官移植中的作用研究进展与临床应用前景OA
Research progress and clinical application prospects of heparin-binding protein in organ transplantation
肝素结合蛋白(HBP)是由活化中性粒细胞释放的促炎颗粒蛋白,兼具调节血管通透性作用,在感染性疾病中具有重要病理意义.近年来,HBP因其在败血症、急性肺损伤及器官移植等情境中的免疫激活作用而被关注,并被提出作为早期感染和炎症的潜在生物标志物.尽管动物研究已有初步进展,临床证据仍有待拓展.因此,本文聚焦HBP在移植相关并发症中的作用机制,探讨其预测感染风险、介导缺血-再灌注损伤与排斥反应的潜在路径,并评估中和抗体、肝素衍生物、白蛋白等干预策略的可行性.HBP在移植炎症反应调控中的关键地位,可能为术后感染监测与个体化干预提供新靶点.
Heparin-binding protein(HBP)is a pro-inflammatory granule protein released by activated neutrophils,known for its role in modulating vascular permeability and its pathological significance in infectious diseases.In recent years,HBP has garnered attention due to its immune-activating effects in contexts such as sepsis,acute lung injury and organ transplantation.It has been proposed as a potential biomarker for early detection of infection and inflammation.While preliminary progress has been made in animal studies,clinical evidence remains limited.Therefore,this article focuses on the mechanism of action of HBP in transplantation-related complications,explores its potential pathways for predicting infection risk,mediating ischemia-reperfusion injury and rejection,and evaluates the feasibility of intervention strategies such as neutralizing antibodies,heparin derivatives and albumin.The pivotal role of HBP in regulating inflammatory responses post-transplant may offer a novel target for postoperative infection monitoring and personalized therapeutic interventions.
张程昶;李若竹;王叶岐鸣;代辰
430030 武汉,华中科技大学附属同济医学院附属同济医院器官移植研究所430030 武汉,华中科技大学附属同济医学院附属同济医院器官移植研究所430030 武汉,华中科技大学附属同济医学院附属同济医院器官移植研究所430030 武汉,华中科技大学附属同济医学院附属同济医院器官移植研究所
医药卫生
肝素结合蛋白器官移植生物标志物炎症反应排斥反应缺血-再灌注损伤感染免疫调控
Heparin-binding proteinOrgan transplantationBiomarkerInflammatory responseRejectionIschemia-reperfusion injuryInfectionImmune regulation
《器官移植》 2026 (1)
51-60,10
国家自然科学基金(81900368)
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