巨噬细胞在肾移植抗体介导的排斥反应中的作用及临床应用进展OA
The role and clinical application progress of macrophages in antibody-mediated rejection in kidney transplantation
肾移植是终末期肾衰竭最有效的治疗方法,而抗体介导的排斥反应是移植肾晚期丢失的主要原因.巨噬细胞作为先天免疫的核心效应细胞,在抗体介导的排斥反应的启动、进展和组织损伤中扮演关键角色.本文就抗体介导的排斥反应不同阶段巨噬细胞极化状态时空动态演变、巨噬细胞极化的关键信号通路的精细调控、巨噬细胞相关分子以及靶向巨噬细胞治疗的应用前景等进行综述,深入解析巨噬细胞在抗体介导的排斥反应中的研究进展,以期为开发基于巨噬细胞的精准诊断工具、抗体介导的排斥反应的新型免疫干预靶点提供重要理论依据,最终推动肾移植长期预后的改善.
Kidney transplantation is the most effective treatment for end-stage renal failure,and antibody-mediated rejection remains the leading cause of late allograft loss.Macrophages,as central effectors of innate immunity,play a crucial role in the initiation,progression and tissue damage of antibody-mediated rejection.This article reviews the spatiotemporal dynamic evolution of macrophage polarization status in different stages of antibody-mediated rejection,the fine regulation of key signaling pathways for macrophage polarization,macrophage related molecules and the application prospects of targeted macrophage therapy.In depth analysis of the research progress of macrophages in antibody-mediated rejection,aiming to provide important theoretical basis for the development of precision diagnostic tools based on macrophages and novel immune intervention targets for antibody mediated rejection,ultimately promoting the improvement of long-term prognosis in kidney transplantation.
汤寰;桂泽平;顾民;王子杰
210003 南京,南京医科大学第二附属医院泌尿外科 泌尿外科疾病防治省高校重点实验室210003 南京,南京医科大学第二附属医院泌尿外科 泌尿外科疾病防治省高校重点实验室210003 南京,南京医科大学第二附属医院泌尿外科 泌尿外科疾病防治省高校重点实验室210003 南京,南京医科大学第二附属医院泌尿外科 泌尿外科疾病防治省高校重点实验室
医药卫生
巨噬细胞肾移植抗体介导的排斥反应供者特异性抗体干扰素-γ炎症反应纤维化免疫治疗
MacrophageKidney transplantationAntibody-mediated rejectionDonor specific antibodyInterferon-γInflammationFibrosisImmunotherapy
《器官移植》 2026 (1)
44-50,7
国家自然科学基金(82470790、81900684)江苏省科技计划专项资金(重点研发计划社会发展)(BE2023784)
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