原发性高血压发病机制以及中药调控原发性高血压的研究进展OA

Essential hypertension is the most common chronic disease in the cardiovascular system,with numerous complications,which seriously reduces the living standards of patients.However,its pathogenesis is complex and not yet fully understood.This article summarizes the latest related studies.The main pathogenesis is as follows:activation of the renin-angiotensin system(RAS),inflammatory responses in some cells and organs,increased oxidative stress and changes in total antioxidant capacity,dysfunction of vascular endothelial cells,changes in intestinal flora,etc.For the treatment of essential hypertension,Western medicine is the main approach.However,while applying Western medicine to treat essential hypertension,it is also necessary to apply syndrome differentiation and treatment.The use of traditional Chinese medicine and its related compound preparations can better improve the clinical symptoms of patients,protect target organs,and reduce the occurrence of adverse reactions.Traditional Chinese medicine can respectively inhibit the proliferation of vascular smooth muscle cells by regulating the PI3K/Akt signaling pathway,TGF-β/Smads signaling pathway,NF-κB signaling pathway,NLRP3 signaling pathway and Wnt/β-catenin signaling pathway.It regulates hypertension in the body by inhibiting inflammatory responses,improving vascular structure remodeling,protecting vascular endothelium,and regulating intestinal flora,etc.This article reviews the pathogenesis of essential hypertension and summarizes the research results of traditional Chinese medicine extracts and compound prescriptions regulating essential hypertension through different signaling pathways,with the aim of providing strategies at the traditional medical level for the prevention and treatment of the disease.