柴银亚甲方治疗风热痰阻型亚急性甲状腺炎的疗效及对疼痛因子、免疫功能指标、甲状腺功能指标的影响OA

Objective To analyze the efficacy of Chaiyinya sub-party A in the treatment of subacute thy-roiditis with wind,heat and phsputum obstruction and its influence on pain factors,immune function indexes and thyroid function indexes.Methods A total of 100 patients with subacute thyroiditis admitted to the hospi-tal from July 2023 to July 2024 were selected as the research objects,and they were divided into the basic group and the Chaiyin sub-party A group by random number table method,with 50 cases in each group.The basic treatment group was treated with conventional western medicine,and the Chaiyin sub-party A group was treated with Chaiyin sub-party A on the basis of the basic treatment group.The basic treatment group and Chaiyin sub-party A group were treated for 4 weeks.After the treatment,the clinical efficacy was compared between the basic group and the Chaiyin sub-party A group.The scores of TCM syndromes(fever,sore throat,neck enlargement,headache,thyroid pain,hoarseness)were compared between the basic group and the Chaiyin sub-party A group before and after treatment.The levels of immune function indexes[complement C3,immunoglobulin(Ig)A,amyloid A(SAA),tumor necrosis factor(TNF)-β]and pain factors[serum pros-taglandin E2(E2),bradykinin]were detected in all patients.The levels of inflammatory indicators and thyroid function indicators[thyroid stimulating hormone(TSH),free thyroxine(FT4),thyroglobulin antibody(TgAb),free triiodothyronine(FT3)]were detected in all patients.The swelling time and pain resolution time of all patients were recorded.The adverse reactions of all patients during treatment were recorded.All patients were followed up for 3 months after treatment,and the recurrence of all patients was recorded.Results In the basic group,2 cases dropped out,and 48 cases were finally included.In Chaiyin sub-party A group,3 cases dropped out,and 47 cases were finally included.The total effective rate of Chaiyin sub-party A group was 95.74%,which was higher than 79.17%of the basic group,and the difference was statistically sig-nificant(P<0.05).After treatment,the scores of fever,sore throat,anterior neck swelling,headache,thyroid pain and hoarseness in the basic group and the Chaiyin sub-party A group were lower than those before treat-ment,and the scores of fever,sore throat,anterior neck swelling,headache,thyroid pain and hoarseness in the Chaiyin sub-party A group were lower than those in the basic group,and the differences were statistically sig-nificant(P<0.05).After treatment,the levels of complement C3,IgA,SAA,TNF-β in the basic group and the Chaiyin sub-party A group were lower than those before treatment,and the levels of complement C3,IgA,SAA,TNF-β in the Chaiyin sub-party A group were lower than those in the basic group,and the differences were statistically significant(P<0.05).The levels of E2,bradykinin in the basic group and the Chaiyin sub-party A group after treatment were lower than those before treatment,and the levels of E2 bradykinin in the Chaiyin sub-party A group after treatment were lower than those in the basic group,and the differences were statistically significant(P<0.05).After treatment,the levels of FT4,TgAb and FT3 in the basic group and the Chaiyin sub-party A group were lower than those before treatment,and the levels of FT4,TgAb and FT3 in the Chaiyin sub-party A group were lower than those in the basic group,and the differences were statistical-ly significant(P<0.05).The TSH level of the basic group and the Chaiyin sub-party A group after treatment was higher than that before treatment,and the TSH level of the Chaiyin sub-party A group after treatment was higher than that of the basic group,and the differences were statistically significant(P<0.05).After treatment,the swelling time and pain subsiding time of the Chaiyin sub-party A group were shorter than those of the basic group,and the differences were statistically significant(P<0.05).No obvious adverse reactions occurred in the basic group and the Chaiyin sub-party A group during the treatment.After 3 months of follow-up,the recurrence rate of Chaiyin sub-party A group(2.13%)was lower than that of basic group(16.67%),and the difference was statistically significant(P<0.05).Conclusion Chaiyin sub-party A in the treatment of subacute thyroiditis can decrease the levels of inflammatory factors and pain factors,regulate immune func-tion,improve thyroid function,improve clinical efficacy,with low recurrence rate and high safety.