血清PDK1、PAX8、DKK1对子宫内膜异位症的诊断价值OA

Objective To investigate the levels and diagnostic value of serum 3-phosphatidylinositol-de-pendent protein kinase 1(PDK1),paired box gene 8(PAX8)and Dickkopf-related protein 1(DKK1)in pa-tients with endometriosis(EMs).Methods A total of 100 EMs patients admitted to the hospital from Decem-ber 2021 to December 2024 were selected as the observation group,and they were divided into mild group(43 cases)and moderate to severe group(57 cases)according to the severity of the disease.In addition,100 healthy female who underwent physical examination in the hospital during the same period were selected as the control group.The serum levels of PDK1,PAX8 and DKK1 in all subjects were detected by enzyme-linked immunosorbent assay.Pearson correlation analysis was used to analyze the correlation between serum PDK1,PAX8,DKK1 levels and American Society of Fertility Medicine revised staging of endometriosis(r-AFS)scores in EMs patients.Multivariate Logistic regression was used to analyze the influencing factors of EMs.The receiver operating characteristic(ROC)curve was used to analyze the diagnostic value of serum PDK1,PAX8 and DKK1 for EMs.Results The proportion of dysmenorrhea patients and serum PDK1,PAX8,and DKK1 levels in the observation group were higher than those in the control group,and the differences were statistically significant(P<0.05).The serum levels of PDK1,PAX8 and DKK1,the r-AFS scores,in the moderate to severe group were higher than those in the mild group,and the differences were statistically sig-nificant(P<0.05).Pearson correlation analysis showed that the serum levels of PDK1,PAX8 and DKK1 in EMs patients were positively correlated with r-AFS scores(r=0.411,0.557,0.531,P<0.05).Multivariate Logistic regression analysis showed that the increased levels of serum PDK1,PAX8 and DKK1 were risk fac-tors for EMs(P<0.05).The results of ROC curve analysis showed that the area under the curve(AUC)of the combination of serum PDK1,PAX8,and DKK1 in the diagnosis of EMs was 0.893,which was greater than the AUC of 0.782,0.764 and 0.766 of the three alone,and the differences were statistically significant(Z=4.315,4.496,4.087,P<0.05).Conclusion The serum levels of PDK1,PAX8 and DKK1 in EMs patients are increased,and the combination of the three indicators has a good diagnostic value for EMs.