溃疡性结肠炎患者血清PRDX1、CCL-25水平及其与病情严重程度、临床转归的关系OA

Objective To investigate the serum levels of peroxiredoxin 1(PRDX1)and CC motif chemo-kine ligan-25(CCL-25)in patients with ulcerative colitis(UC)and their relationship with disease severity and clinical outcome.Methods A total of 218 UC patients admitted to Kizilsu Kirgiz Autonomous Prefecture Peo-ple's Hospital from March 2021 to June 2024 were selected as the UC group.According to the severity of the disease,they were divided into mild group,moderate group and severe group,and according to the clinical out-come of 6 months,they were divided into poor outcome group and good outcome group.In addition,109 healthy people who underwent physical examination in the People's Hospital of Kizilsu Kirgiz Autonomous Prefecture during the same period were selected as the control group.The serum PRDX1 and CCL-25 levels of all subjects were detected by enzyme-linked immunosorbent assay.Multivariate Logistic regression was used to analyze the influencing factors of poor clinical outcomes in UC patients.Receiver operating characteristic(ROC)curve was drawn to analyze the predictive value of serum PRDX1 and CCL-25 for poor clinical out-comes in UC patients.Results The serum levels of PRDX1 and CCL-25 in UC group were higher than those in control group,and the differences were statistically significant(P<0.05).The serum PRDX1 and CCL-25 levels in the moderate and severe groups were higher than those in the mild group,and the serum PRDX1 and CCL-25 levels in the severe group were higher than those in the moderate group,and the differences were sta-tistically significant(P<0.05).The course of disease in the poor outcome group was longer than that in the good outcome group,and the proportion of severe patients and serum PRDX1 and CCL-25 levels were higher than those in the good outcome group,and the differences were statistically significant(P<0.05).Multivari-ate Logistic regression analysis showed that severe disease severity,increased PRDX1 level and CCL-25 level were independent risk factors for poor clinical outcomes in UC patients(P<0.05).The results of ROC curve analysis showed that the area under the curve(AUC)of serum PRDX1 and CCL-25 combined to predict poor clinical outcomes of UC patients was 0.888,which was greater than the AUC predicted by serum PRDX1 and CCL-25 alone(0.782,0.794),and the differences were statistically significant(Z=4.316,3.814,P<0.001).Conclusion The serum levels of PRDX1 and CCL-25 in UC patients are increased,which are closely related to the aggravation of disease severity and poor clinical outcome.The combination of serum PRDX1 and CCL-25 has a high predictive value for the clinical poor outcome of UC patients.