冠心病合并高血压患者血浆GPC4、TMAO水平及其与PCI术后发生不良事件的关系OA

Objective To investigate the plasma levels of glypican 4(GPC4)and trimethylamine oxide(TMAO)in patients with coronary heart disease and hypertension and their relationship with adverse events after percutaneous coronary intervention(PCI).Methods A total of 238 patients with coronary heart disease complicated with hypertension admitted to the hospital from March 2021 to March 2024 were selected as the study group,and 230 patients with simple coronary heart disease admitted to the hospital during the same pe-riod were selected as the control group.Patients with coronary heart disease and hypertension were treated with PCI.The study group was divided into occurrence group and non-occurrence group according to the oc-currence of adverse events within 1 year after PCI.The plasma levels of GPC4 and TMAO were measured by enzyme-linked immunosorbent assay(ELISA).Multivariate Logistic regression was used to analyze the influ-encing factors of adverse events in patients with coronary heart disease and hypertension after PCI.Receiver operating characteristic(ROC)curve was used to analyze the predictive value of plasma GPC4 and TMAO for adverse events in coronary heart disease patients with hypertension after PCI.Results The plasma levels of GPC4 and TMAO in the study group were significantly higher than those in the control group(P<0.05).The proportion of diabetes,the proportion of heart rate>100 beats/min,the proportion of the number of im-planted stents>2,vascular stenosis,and the levels of total cholesterol,low-density lipoprotein cholesterol,GPC4,and TMAO in the occurrence group were significantly higher than those in the non-occurrence group(P<0.05).Multivariate Logistic regression analysis showed that diabetes,heart rate>100 beats/min,num-ber of implanted stents>2,and increased plasma GPC4 and TMAO levels were risk factors for adverse e-vents in patients with coronary heart disease and hypertension after PCI(P<0.05).The results of ROC curve analysis showed that the area under the curve(AUC)of plasma GPC4 and TMAO combined to predict ad-verse events after PCI in patients with coronary heart disease and hypertension was 0.900,which was greater than the AUC of plasma GPC4 and TMAO predicted alone(0.820,0.810),and the differences were statisti-cally significant(Z=2.179,2.245,P=0.029,0.025).Conclusion The plasma levels of GPC4 and TMAO in CHD patients with hypertension are significantly increased,and are closely related to the occurrence of adverse events after PCI.The combined detection of GPC4 and TMAO has a high predictive value for the occurrence of adverse events in CHD patients with hypertension after PCI,and may increase the accuracy of prediction.