血清galectin-10、STAT3、CCL19水平与慢性湿疹患者疾病严重程度相关OA
Level of serum galectin-10,STAT3 and CCL19 is correlated with disease severity in patients with chronic eczema
目的 探究血清半乳糖凝集素-10(Gal-10)、信号传导及转录激活因子 3(STAT3)、趋化因子配体 19(CCL19)水平与慢性湿疹患者病情之间的关联性.方法 选取 2022 年 10 月至 2024 年 10 月在郑州市第七人民医院门诊收治的 104 例慢性湿疹患者,组成病例组.依据湿疹面积及严重度指数(EASI)评分将其分为轻(EASI评分≤10 分,43 例)、中(10 分＜EASI评分≤19 分,36 例)和重度组(EASI评分≥20 分,25 例);同时选取同期 60 例体检健康者,组成对照组.ELISA检测血清Gal-10、STAT3、CCL19 水平.Spearman相关性分析患者血清Gal-10、STAT3、CCL19 水平与EASI评分的相关性;Logistic回归分析影响患者病情的因素;受试者工作特征(ROC)曲线评估血清Gal-10、STAT3、CCL19 水平对湿疹严重程度的诊断价值.结果 与对照组相比,病例组患者血清Gal-10、STAT3、CCL19 水平均显著上升(P＜0.05).与轻度组相比,中和重度组患者的EASI评分及血清Gal-10、STAT3、CCL19 水平均显著上升(P＜0.05);且重度组显著高于中度组(P＜0.05).慢性湿疹患者血清Gal-10、STAT3、CCL19 水平与EASI评分均呈正相关(r=0.606、0.417、0.507,P＜0.05).EASI评分及血清Gal-10、STAT3、CCL19 水平上升均是影响慢性湿疹病情加重的危险因素(P＜0.05).血清Gal-10、STAT3、CCL19 单独及联合诊断慢性湿疹严重程度的曲线下面积(AUC)分别为 0.827、0.811、0.803 和 0.914,联合诊断效能优于 3 者单独检测(Z三者联合-Gal-10=2.703,Z三者联合-STAT3=2.251,Z三者联合-CCL19=2.795,P均＜0.05).结论 慢性湿疹患者血清Gal-10、STAT3、CCL19 水平升高,与疾病严重程度显著相关,三者联合检测对慢性湿疹严重程度的诊断价值更高.
Objective To investigate potential correlation of serum galectin-10(Gal-10),signal transducer,activa-tor of transcription 3(STAT3)and C-C chemokine ligand 19(CCL19)with severity of chronic eczema.Methods From October 2022 to October 2024,104 patients admitted to the 7th People's Hospital of Zhengzhou with chronic eczema were reviewed.Based on implicated area of eczema and severity index(EASI)score,they were assigned into mild group(EASI score≤10 points,43 cases),moderate group(10 points＜EASI score≤19 points,36 ca-ses),and severe group(EASI score≥20 points,25 cases).Meantime,60 healthy individuals from routine physi-cal check were selected as control group.ELISA was used to detect serum Gal-10,STAT3,and CCL19.Spearman correlation was performed to analyze the correlation between serum Gal-10,STAT3,CCL19 levels with EASI score in patients.Logistic regression was performed to analyze the factors affecting the condition of patients.Receiver operat-ing characteristic(ROC)curves were used to evaluate the diagnostic value of serum Gal-10,STAT3,and CCL19 for the severity of chronic eczema.Results The case group had manifestly higher serum Gal-10,STAT3 and CCL19 than control group(P＜0.05).The moderate and severe groups had conspicuous higher EASI scores and serum Gal-10,STAT3 and CCL19 than mild group(P＜0.05);And with severe group being conspicuously higher than moder-ate group(P＜0.05).Serum Gal-10,STAT3,CCL19 in patients with chronic eczema were positively correlated with EASI score(r=0.606,0.417,0.507,P＜0.05).The elevated EASI score,serum Gal-10,STAT3 and CCL19 were all believed to be risk factors to aggravate chronic eczema(P＜0.05).The area under the curve(AUC)of serum Gal-10,STAT3,CCL19 alone and in combination for diagnosing the severity of chronic eczema was 0.827,0.811,0.803,and 0.914,respectively.The combined diagnostic efficacy was superior to the individual detection of the three(Zthree combination-Gal-10=2.703,Zthree combination-STAT3=2.251,Zthree combination-CCL19=2.795,all P＜0.05).Conclusions The serum level of Gal-10,STAT3 and CCL19 in patients with chronic eczema are elevated and correlated with se-verity of the disease.The combined detection of the three combined index factor may support clinical evaluation of the severity of chronic eczema.
孟小卉;姜诗谣;杨怡
郑州市第七人民医院 皮肤科,河南 郑州 450000郑州市第七人民医院 皮肤科,河南 郑州 450000郑州市第七人民医院 皮肤科,河南 郑州 450000
医药卫生
半乳糖凝集素-10信号传导及转录激活因子3趋化因子配体19慢性湿疹疾病严重程度
galectin-10signal transducer and activator of transcription 3C-C chemokine ligand 19chronic eczemaseverity of disease
《基础医学与临床》 2026 (1)
16-21,6
河南省医学科技攻关计划(LHGJ2022001)
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