新生化颗粒联合麦角新碱促进产后子宫复旧的作用及对血液流变学、血清激素及HIF-1α、MMP-9水平的影响OA

Objective To investigate the efficacy of Xinshenghua Granules combined with ergometrine in promoting postpartum uterine involution,and to observe their effects on hemorheology,serum hormones,and levels of hypoxia-inducible factor-1α(HIF-1α)and matrix metalloproteinase-9(MMP-9).Methods A total of 120 women undergoing cesarean section at the Third Affiliated Hospital of Zhengzhou University from August 2022 to September 2024 were randomized into two groups using a random number table method:the observation group(n=60)and the control group(n=60).The control group received ergometrine combined with oxytocin via uterine body injection,while the observation group received additional oral administration of Xinshenghua Granules for 4 consecutive days.Postpartum hemorrhage,uterine involution,volume of lochia rubra,and durations of lochia and lochia rubra were compared between the two groups.Changes in hemorheology,serum hormones[luteinizing hormone(LH),estradiol(E2),follicle-stimulating hormone(FSH)],HIF-1α,and MMP-9 levels were assessed before delivery and on postpartum day 4.Adverse reactions were recorded.Results(1)On postpartum day 1,no significant difference was observed in the descent of the uterine fundus between the two groups(P＞0.05).By postpartum day 4,the observation group showed significantly greater uterine fundal descent than the control group(P＜0.01).(2)The observation group exhibited significantly less lochia rubra volume and shorter durations of both lochia and lochia rubra compared to the control group(P＜0.05).(3)No significant differences were found between the two groups in blood loss at 2-hour and 24-hour postpartum or in the incidence of postpartum hemorrhage(blood loss＞1 000 mL within 24 hours)(P＞0.05).(4)On postpartum day 4,both groups showed significant reductions in high-shear whole blood viscosity,low-shear whole blood viscosity,plasma viscosity,and erythrocyte aggregation index compared to pre-delivery levels(P＜0.05),with the observation group demonstrating significantly greater improvements in all hemorheological parameters than the control group(P＜0.01).(5)On postpartum day 4,both groups exhibited increased serum LH and E2 levels(P＜0.05)and decreased serum FSH levels(P＜0.05)compared to pre-delivery levels.The observation group showed significantly greater increases in LH and E2 and a greater decrease in FSH than the control group(P＜0.01).(6)On postpartum day 4,both groups demonstrated decreased serum HIF-1α and MMP-9 levels compared to pre-delivery levels(P＜0.05),with the observation group exhibiting significantly greater reductions than the control group(P＜0.01).(7)The total incidence of adverse reactions was 5.00%(3/60)in the observation group and 8.33%(5/60)in the control group,with no statistically significant difference(χ2=0.134,P＞0.05).Conclusion Xinshenghua Granules combined with ergometrine effectively promote uterine involution and lochia discharge,improve hemorheological parameters,enhance local blood circulation,regulate sex hormone levels,and reduce serum MMP-9 and HIF-1α levels in postpartum women,thereby accelerating uterine recovery with a favorable safety profile.