程序性细胞死亡配体1与头颈癌风险的孟德尔随机化研究OA
A Mendelian randomization study of programmed cell death ligand 1 with the risk of head and neck cancer
目的 评估程序性细胞死亡配体1(PD-L1)与不同类型头颈癌风险之间的因果关系.方法 利用大规模遗传数据进行孟德尔随机化(MR)分析,通过逆方差加权法(IVW)、孟德尔随机化-艾格法(MR-Egger)、简单模式法和加权中位数法等方法评估PD-L1与不同类型头颈癌风险之间的因果关系.同时采用 MR-Egger和孟德尔随机化多效性残差和离群值(MR-PRESSO)来评估水平多效性,Cochran's Q检验来评估异质性,留一法实验来评估敏感性.结果 遗传预测结果显示,PD-L1与头颈部鳞状细胞癌(HNSCC)(OR=1.000 3,95%CI:1.000 0～1.000 6,P=0.049)、口腔及口咽癌(OC&PC)(OR=1.000 3,95%CI:1.000 1～1.000 6,P=0.018)存在因果关系.结论 本研究分析表明,PD-L1是HNSCC、OC&PC的危险因素.
Objective This study aimed to assess the causal relationship between programmed cell death ligand 1(PD-L1)and the risk of head and neck cancer.Methods Mendelian randomization(MR)was performed using large-scale ge-netic data to evaluate the causal relationship between PD-L1 and the risk of different types of head and neck cancers via inverse variance weighted(IVW),Mendelian randomization-Egger(MR-Egger),simple mode,and weighted median.Ad-ditionally,MR-Egger and Mendelian randomization pleiotropy residual sum and outlier(MR-PRESSO)were used to ana-lyze horizontal pleiotropy,Cochran's Q test was performed to examine heterogeneity,and leave-one-out experiment was conducted to measure sensitivity.Results The genetic prediction results revealed a causal relationship between PD-L1 and head and neck squamous cell carcinoma(HNSCC)(OR=1.000 3,95%CI:1.000 0-1.000 6,P=0.049)and between PD-L1 and oral cavity and oropharyngeal cancer(OC&PC)(OR=1.000 3,95%CI:1.000 1-1.000 6,P=0.018).Conclu-sion PD-L1 may be a risk factor for the development of HNSCC and OC&PC.
尚宏悦;刘铁军;姚曼曼;路月亭;董博;宋炜晶;张纪傲
河北医科大学第四医院口腔科 石家庄 050000河北医科大学第四医院口腔科 石家庄 050000河北医科大学第四医院口腔科 石家庄 050000河北医科大学第四医院口腔科 石家庄 050000河北医科大学第四医院口腔科 石家庄 050000河北医科大学第四医院口腔科 石家庄 050000河北医科大学第四医院口腔科 石家庄 050000
医药卫生
孟德尔随机化程序性死亡配体1头颈癌风险
Mendelian randomizationprogrammed cell death ligand 1head and neck cancerrisk
《国际口腔医学杂志》 2026 (1)
67-75,9
Central Government Guides Local Science And Technology Development Fund Projects(246Z7762G) 中央引导地方科技发展资金项目(246Z7762G)
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