局部应用环孢素治疗口腔扁平苔藓的有效性和安全性的Meta分析OA

Objective This study aimed to evaluate the efficacy and safety of topical cyclosporine in the treatment of oral lichen planus(OLP)and to provide reference for clinicians.Methods Databases,such as Pubmed,Embase,The Co-chrane Library,Web of Science,CNKI,WanFang Data,and VIP,were searched.The System for Information on Grey Li-terature in Europe(SIGLE)and ClinicalTrials websites were searched online to collect randomized controlled trials(RCTs)of cyclosporine for OLP from the establishment of the database to March 25,2023.Two reviewers independently evalua-ted the study quality and extracted data,and meta-analysis was performed using RevMan(version 5.4)and STATA(ver-sion 14.0)software.Results A total of seven RCT studies on cyclosporine in the treatment of OLP were included,in-cluding 317 patients.Among them,six compared cyclo-sporine with corticosteroid,and one compared cyclospo-rine with placebo.Meta-analysis results showed no sta-tistically significant difference in clinical effectiveness between the cyclosporine and corticosteroid groups[risk ratio(RR)=0.87,95%confidence interval(CI):0.67-1.14,P=0.32].After 4 weeks of treatment,no statistically significant difference was observed in the improvement of pain scores between the cyclosporine and corticosteroid groups(standardized mean difference=-0.23,95%CI:-0.54-0.07,P=0.13).No statistically significant difference was found in the incidence of adverse reactions between the cyclosporine and corticosteroid groups(RR=0.71,95%CI:0.18-2.79,P=0.62).Conclusion Current evidence shows that cyclosporine has no advantage over corticosteroid in terms of clinical efficacy,improvement in pain scores,and safety.More high-quality studies are required to verify the above conclusion due to limitations in the quantity and quality of included studies.