基于Cox模型的颅内动脉瘤血管内介入疗效及预后不良的影响因素分析OA

Objective To explore the effect of endovascular interventional therapy for intracranial aneurysms and the in-fluencing factors of poor prognosis.Methods A total of 90 elderly patients who underwent interventional therapy for aneurysms in the Department of Neurosurgery,the First Affiliated Hospital with Nanjing Medical University from January 2021 to December 2023 were selected as the research subjects.According to the degree of embolization in intracranial aneurysm,they were divided into the complete embolization group(61 cases)and the incomplete embolization group(29 cases).They were also divided into the good prognosis group(55 cases)and the poor prognosis group(35 cases)based on the modified Rankin Scale score.All patients re-ceived endovascular interventional therapy for intracranial aneurysms.Univariate analysis was performed to identify the risk factors for incomplete embolization and poor prognosis in patients,respectively.The indicators with statistically significant differences(P<0.05)were subjected to multivariate Cox regression analysis to explore the risk factors influencing treatment efficacy and poor prog-nosis.Results Comparisons of age,smoking history,hypertension,diabetes mellitus,hyperlipidemia,aneurysm size,aneurysm type,Hunt-Hess grade,and presence of hematoma among patients with different treatment effects and prognoses showed statistically significant differences(P<0.05).Multivariate Cox regression analysis indicated that age,smoking history,hypertension,diabetes mellitus,hyperlipidemia,aneurysm size,aneurysm type,Hunt-Hess grade,and presence of hematoma were all independent influen-cing factors for treatment effects and poor prognosis(P<0.05).Conclusion Before and after endovascular interventional therapy for intracranial aneurysms,corresponding nursing measures should be promptly implemented targeting the risk factors to reduce the risk of adverse prognosis in patients.