86例头颈癌放疗后住院患者发生抢救事件的回顾性分析OA

Objective To summarize the circumstances of rescue events in hospitalized patients after radiotherapy for head and neck cancer in order to provide a reference for clinical decision-making.Methods This study was ap-proved by the hospital's medical ethics committee.A retrospective analysis was conducted on the clinical data of 86 hospitalized patients admitted between 2015 and 2023 for oral and maxillofacial diseases following radiotherapy for head and neck cancer.Based on the occurrence of rescue events,patients were divided into a rescue group(n=20)and a non-rescue group(n=66).In addition,20 healthy subjects matched for age and gender with the rescue group were in-cluded as a control group.First,baseline characteristics were compared between the rescue and non-rescue groups.Sec-ond,a descriptive analysis of the clinical characteristics and rescue events of the rescue group patients was performed.Third,differences in laboratory inflammatory and nutritional indicators,as well as tracheostomy status,were compared between the rescue and non-rescue groups.Fourth,Dolphin Imaging software was used to measure cone beam computed tomography images of the rescue group,non-rescue group,and control group.Upper airway parameters were measured,including the sagittal and coronal diameters of the nasopharyngeal,palatopharyngeal,glossopharyngeal,and laryngopha-ryngeal segments.Results ① A comparison of baseline characteristics between the rescue and non-rescue groups showed no statistically significant differences in age,gender,or body mass index,but the proportion of patients with co-morbid pulmonary diseases was higher in the rescue group(P<0.05).② In the rescue group,the primary reasons for ra-diotherapy were nasopharyngeal carcinoma(65%)and tongue cancer(25%).The mean age was(54.75±11.59)years,with a male-to-female ratio of 3:1.The main reasons for this admission included radio-osteomyelitis in the mandible(55%)and recurrence of oral and maxillofacial tumors or new primary tumors in the oral and maxillofacial region(40%).The primary reason for rescue during hospitalization was dyspnea(55%),followed by acute massive hemorrhage(15%)and cardiac arrest(15%).Rescue events occurred mostly postoperatively(65%),with a median time of occurrence at 5 days post-operatively;30%occurred preoperatively,and 5%occurred intraoperatively.③ Laboratory indicators and tracheostomy status:preoperative and postoperative neutrophil counts,as well as the proportion of patients undergoing tracheostomy,were higher in the rescue group compared to the non-rescue group,while postoperative albumin levels were lower(P<0.05).④ Upper airway measurements:the coronal and sagittal diameters of the nasopharyngeal segment and the coronal diameter of the glossopharyngeal segment were smaller in both the rescue and non-rescue groups com-pared to the control group(P<0.001).Conclusion The data from this study indicate that hospitalized patients experi-encing rescue events after radiotherapy for head and neck cancer often have comorbid pulmonary diseases or tumor re-currence/new primary tumors,and frequently present with dyspnea.They exhibit a higher inflammatory state,poorer nu-tritional status,a greater need for emergency airway intervention,and share a common anatomical basis for dyspnea--upper airway narrowing.Clinical attention should be fully given to high-risk patients with these characteristics.