益气托毒法治疗脾虚夹湿型中重度痤疮OA
The Method of Tonifying Qi to Expel Toxins in Treatment of Moderate-Severe Acne with Spleen Deficiency and Dampness Syndrome
目的:基于益气托毒法,应用自拟加味黄芪茯苓白术汤治疗脾虚夹湿型中重度痤疮患者,观察其对皮肤生理状态、免疫功能、肠道菌群的影响.方法:选取安阳市中医院符合纳入标准的脾虚夹湿型中重度痤疮患者,依据随机数字表随机分为常规组54例和联合组55例.常规组给予盐酸米诺环素胶囊口服,联合组在常规组治疗基础上,给予加味黄芪茯苓白术汤口服,两组均治疗4周.比较两组患者治疗前后中医证候积分、皮肤生理状态、免疫功能、肠道菌群水平的变化情况,并比较临床疗效和不良反应发生率.结果:治疗后,两组中医证候积分、皮脂含量、经皮水分流失值(TEWL)、肠球菌和大肠杆菌水平降低(P<0.05),皮肤水分、T淋巴细胞亚群(CD3+、CD8+)、自然杀伤细胞(NK)、双歧杆菌水平和双歧杆菌/大肠杆菌(B/E)比值升高(P<0.05),且联合组改善情况优于常规组(P<0.01).联合组临床总有效率92.73%(51/55),明显高于常规组79.63%(43/54)(P<0.05);常规组不良反应发生率3.7%(2/54),联合组不良反应发生率5.45%(3/55),两组比较差异无统计学意义(P>0.05).结论:基于益气托毒法,采用自拟加味黄芪茯苓白术汤能够有效提高脾虚夹湿型中重度痤疮患者免疫功能,调节肠道菌群水平,促进皮肤生理状态恢复正常,且安全性较高.
Objective:To explore the efficacy of the self-designed Huangqi Fuling Baizhu Decoction based on the method of tonifying qi to expel toxins in the treatment of patients of moderate-severe acne with spleen deficiency and dampness syndrome,as well as its influence on the skin's physiological state,immune function and intestinal flora.Methods:Patients of moderate-severe acne with spleen deficiency and dampness syndrome in Anyang Hospital of Traditional Chinese Medicine were selected as the research subjects and randomly divided into the control group(54 patients)and the combination group(55 patients)by the random number table.The control group was treated with minocycline hydrochloride capsules orally,while the combination group was treated with the self-formulated Huangqi Fuling Baizhu Decoction on the basis of the treatment of control group.The treatment course lasted 4 weeks in both groups.The TCM syndrome score,skin's physiological state,immune function and intestinal flora level of both groups were compared before and after treatment.The clinical efficacy and adverse reaction rate were compared,too.Result:After treatment,the TCM syndrome score,sebum content,and Transepidermal Water Loss(TEWL)and the levels of Enterococcus and Escherichia coli decreased(P<0.05),while skin moisture,T lymphocyte subsets(CD3+,CD8+),natural killer cells(NK),levels of Bifidobacterium,and Bifidobacterium/Escherichia coli(B/E)increased(P<0.05).The improvement of the combination group was better than the control group(P<0.01).The total clinical effective rate in the combination group was 92.73%(51/55),which was obviously higher than those in the control group 79.63%(43/54);The adverse reaction rate in the control group was 3.7%(2/54)and those in the combination group was 5.45%(3/55),with no statistically significant difference between them(P>0.05).Conclusion:The self-designed Huangqi Fuling Baizhu Decoction based on the method of tonifying qi to expel toxins can effectively enhance the immune function of patients of moderate-severe acne with spleen deficiency and dampness syndrome,regulate the level of intestinal flora,promote the restoration of normalization of the skin's physiological state with a favorable safety profile.
ZHENG Mingjuan;ZHU Hua;SUN Wei
Anyang Hospital of Traditional Chinese Medicine,Anyang 455000,ChinaAnyang Hospital of Traditional Chinese Medicine,Anyang 455000,ChinaAnyang Hospital of Traditional Chinese Medicine,Anyang 455000,China
中重度痤疮脾虚夹湿证益气托毒法加味黄芪茯苓白术汤免疫功能肠道菌群
Moderate-severe acneSpleen deficiency with dampness syndromeMethod of tonifying qi to expel toxinsSelf-designed Huangqi Fuling Baizhu DecoctionImmune functionIntestinal flora
《中医药信息》 2026 (1)
64-69,6
河南省第三批中医药青苗人才项目(豫卫中医药科教[2024]4号)
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