温脾益神汤联合温针灸对阿尔茨海默病患者氧化应激及炎症指标的影响OA
Effect of Wenpi Yishen Decoction Combined with Warm Acupuncture and Moxibustion on Oxidative Stress and Inflammatory Markers in Patients with Alzheimer's Disease
目的:观察温脾益神汤联合温针灸对阿尔茨海默病(AD)患者氧化应激及炎症指标的影响.方法:选取符合纳入标准的120例AD患者,依据随机数字表随机分为对照组和观察组,每组各60例.对照组给予盐酸多奈哌齐片口服,观察组在对照组治疗基础上加用温脾益神汤联合温针灸治疗,两组均连续治疗3个月.比较两组治疗前后中医主症、次症和证候评分;采用简易智能精神状态量表(MMSE)、阿尔茨海默病评定量表-认知部分(ADAS-cog)和改良长谷川痴呆量表(HDS-R)评价两组患者治疗前后痴呆程度和认知功能;检测两组治疗前后血清β淀粉样蛋白(amyloid β-protein,Aβ)、牛磺酸(taurine,Tau)蛋白、白细胞介素-6(interleukin-6,IL-6)、肿瘤坏死因子-α(TNF-α)、同型半胱氨酸(Hcy)、过氧化氢酶(CAT)、超氧化物歧化酶(SOD)、丙二醛(MDA)水平;比较两组临床疗效和不良反应发生情况.结果:对照组临床总有效率为71.67%(43/60),观察组临床总有效率为91.67%(55/60),两组比较差异有统计学意义(P<0.05).与治疗前比较,治疗后两组患者中医主症、次症和证候评分、ADAS-cog评分、Aβ、Tau蛋白、TNF-α、IL-6、Hcy、MDA含量均降低(P<0.05),MMSE、HDS-R评分、CAT、SOD均较治疗前升高(P<0.05);治疗后组间比较,观察组中医主症、次症和证候评分、ADAS-cog评分、Aβ、Tau蛋白、TNF-α、IL-6、Hcy、MDA低于对照组(P<0.05),MMSE、HDS-R评分、CAT、SOD高于对照组(P<0.05).结论:温脾益神汤联合温针灸治疗AD患者临床疗效较好,可明显改善认知功能和痴呆程度,抑制炎症反应,降低氧化应激水平,且安全性较佳.
Objective:To observe the effect of Wenpi Yishen Decoction combined with warm acupuncture and moxibustion on oxidative stress and inflammatory markers in patients with Alzheimer's disease(AD).Methods:A total of 120 patients with AD who met the inclusion criteria were randomly divided into a control group and an observation group,with 60 cases in each group.The control group was treated with donepezil hydrochloride tablets orally,while the observation group received the same treatment plus Wenpi Yishen Decoction combined with warm acupuncture and moxibustion.Both groups were treated for 3 months.The primary and secondary traditional Chinese medicine(TCM)symptoms and syndromes scores,as well as the Mini-Mental State Examination(MMSE),Alzheimer's Disease Assessment Scale-Cognitive Subscale(ADAS-cog)and Revised Hasegawa's Dementia Scale(HDS-R),were used to assess the cognitive function and dementia level before and after treatment.The levels of serum β-amyloid protein(Aβ),tau protein(Tau),interleukin-6(IL-6),tumor necrosis factor-α(TNF-α),homocysteine(Hcy),catalase(CAT),superoxide dismutase(SOD),and malondialdehyde(MDA)were measured.Clinical efficacy and adverse reactions were compared between the two groups.Results:The total clinical effective rate in the control group was 71.67%(43/60),while the total clinical effective rate in the observation group was 91.67%(55/60),with a statistically significant difference(P<0.05).Compared with pre-treatment,both groups showed a significant decrease in the primary and secondary TCM symptoms and syndromes scores,ADAS-cog scores,Aβ,Tau,TNF-α,IL-6,Hcy,and MDA levels(P<0.05),while scores of the MMSE and HDS-R,as well as levels of CAT and SOD,increased significantly compared with baseline(P<0.05).After treatment,the observation group showed lower TCM symptoms,ADAS-cog scores,Aβ,Tau,TNF-α,IL-6,Hcy,and MDA levels,and higher in the scores of the MMSE and HDS-R,as well as levels of CAT and SOD compared to the control group(P<0.05).Conclusion:Wenpi Yishen Decoction combined with warm acupuncture and moxibustion shows good clinical efficacy in treating patients with AD,significantly improving cognitive function and dementia level,inhibiting inflammation,and reducing oxidative stress,with good safety.
LI Peng;LIU Yingli;LUO Tong;WANG Lerong;CHENG Aijun
Jining Hospital of Xiyuan Hospital,China Academy of Chinese Medical Sciences,Jining 272000,ChinaJining Public Health Medical Center,Jining 272000,ChinaJining Hospital of Xiyuan Hospital,China Academy of Chinese Medical Sciences,Jining 272000,ChinaJining Hospital of Xiyuan Hospital,China Academy of Chinese Medical Sciences,Jining 272000,ChinaJining Hospital of Xiyuan Hospital,China Academy of Chinese Medical Sciences,Jining 272000,China
温脾益神汤温针灸阿尔茨海默病氧化应激炎症临床疗效
Wenpi Yishen DecoctionWarm acupuncture and moxibustionAlzheimer's diseaseOxidative stressInflammationClinical efficacy
《中医药信息》 2026 (1)
58-63,6
山东中医药科技项目(M-2022065)
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