茵陈蒿汤对胆汁淤积性肝损伤的干预作用及调控机制OA

Cholestatic liver injury refers to the bile production,secretion,and excretion disorder caused by various reasons.It induces liver injury,metabolic disorders,and dysfunction of the hepatobiliary system,which can further develop into liver fibrosis,cirrhosis,liver failure,and even death.At present,the preferred drug for clinical treatment is ursodeoxycholic acid,which,however,induces adverse reactions and is intolerant in some patients.Yinchenhao Tang is a representative prescription of traditional Chinese medicine for the treatment of jaundice due to Yang jaundice.It has the effects of clearing heat,eliminating dampness,and removing jaundice and has shown good therapeutic effect in long-term clinical application.Modern pharmacological studies have found that this prescription has anti-inflammatory,anti-oxidation,bile acid balance-regulating,hepatocyte apoptosis-inhibiting and other liver-protecting effects.This paper reviews the relevant clinical and animal experimental studies on Yinchenhao Tang in the treatment of cholestatic liver injury in recent years.Yinchenhao Tang can intervene in the progression of cholestatic liver injury by regulating bile acid metabolism and excretion,reducing inflammatory response,inhibiting oxidative stress,alleviating endoplasmic reticulum stress,inhibiting hepatocyte apoptosis,and protecting intestinal mucosal barrier.This paper systematically expounds the molecular mechanisms by which Yinchenhao Tang regulates cholestatic liver injury that are confirmed by current research,aiming to provide reference for the clinical application and in-depth study of Yinchenhao Tang.