基于"正虚痰瘀"理论探讨线粒体稳态失调与泛血管疾病的关系OA

Panvascular diseases represent systemic vascular disorders characterized by atherosclerosis as their core pathological feature.Their incidence rates continue to rise,posing significant challenges for clinical management.Based on Traditional Chinese Medicine(TCM)theory of"positive deficiency phlegm stasis",this study delved into the pivotal role of mitochondrial homeostasis dysregulation in the pathogenesis and progression of pan-vascular diseases,along with its intrinsic connection to TCM pathogenesis.Mitochondrial homeostasis dysregulation pervades the entire course of these diseases,with mitochondrial oxidative stress serving as the initiating factor.Excessive reactive oxygen species(ROS)trigger endothelial dysfunction,lipid accumulation,and inflammatory initiation.Additionally,the imbalance between mitochondrial autophagy and apoptosis constitutes a pivotal link in disease progression.Excessive or insufficient autophagy may lead to the accumulation of damaged mitochondria and excessive cellular apoptosis,thereby promoting plaque instability.Furthermore,mitochondrial metabolic reprogramming impairs energy supply and function in vascular wall cells,hindering subsequent vascular repair.These pathological processes constitute the microscopic manifestation of the core pathogenesis,which is characterized by"the intermingle of phlegm and stasis and the deficiency of healthy Qi".Specifically,the endogenous phlegm-turbidity drives mitochondrial oxidative stress injuries,the mutual entanglement of phlegm and stasis induces an imbalance between mitochondrial autophagy and apoptosis,while deficiency of healthy Qi propels mitochondrial energy metabolism disorders and reprogramming.In view of this,this study proposed to employ phlegm-resolving and turbidity-clearing methods to mitigate mitochondrial oxidative stress injuries,phlegm-resolving and blood-activating methods to regulate mitochondrial autophagy and apoptosis,and spleen-tonifying and kidney-nourishing methods to modulate mitochondrial metabolic reprogramming.This approach can prevent and treat panvascular diseases by multi-target regulation of mitochondrial homeostasis,providing a theoretical framework and therapeutic strategies for the prevention and treatment of panvascular diseases through integrated Chinese and Western medicine.