基于"伏邪"理论探讨泛血管疾病发病机制及防治策略OA

Panvascular diseases refer to systemic vascular lesions with atherosclerosis as its common pathological basis,affecting the vascular networks of multiple organs such as the heart,brain,kidneys,limbs,and large arteries.This concept transcends the limitations of traditional classifications and promotes comprehensive vascular health management through multidisciplinary collaboration.Latent pathogenic factors play a critical role in the pathogenesis of panvascular diseases.They remain dormant within the body until finding an opportunity to manifest,which aligns closely with the characteristics of panvascular diseases,including their early covert progression and subsequent adverse vascular events.According to the"latent pathogen"theory,this article elucidates the pathogenesis of panvascular diseases from latent pathogen,vessel damage,and healthy Qi consumption.It posits that the disease onset involves a pathological process progressing from Qi to blood,with endothelial injury serving as the initiating factor.Disease progression encompasses changes from blood to vessels,with inflammatory responses accelerating the disease course.A comprehensive traditional Chinese medicine(TCM)based prevention and treatment system has been developed,dividing the disease course into three stages.In the early stage,pathogenic factors lurk in the vessels,primarily manifesting as abnormal lipid metabolism.In the middle stage,pathogenic factors evolve,leading to inflammatory cascade reactions.In the late stage,pathogenic factors become excessive while positive factors decline,resulting in abnormal energy metabolism.Three core therapeutic approaches-invigorating the spleen and resolving phlegm,activating blood and resolving stasis,and reinforcing healthy Qi and nourishing deficiency-have been established to address key pathological links.In conjunction with modern medical research,the mechanisms of these methods in regulating lipid metabolism,inhibiting inflammatory responses,and modulating energy metabolism to prevent and treat panvascular diseases are explained.It is anticipated that this theoretical framework will enrich the diagnostic and therapeutic thinking in TCM for panvascular diseases and provide a theoretical foundation for constructing TCM-characteristic prevention and treatment plans for panvascular diseases.