补肾法治疗泛血管"免疫-代谢-遗传"轴机制OA

Pan vascular disease(PVD)is a systemic vascular disorder that has become the leading cause of death among the Chinese residents,and there is currently a lack of effective systemic treatment options.Clinical practice has found that the traditional Chinese medicine(TCM)method of kidney tonification can effectively intervene in PVD and target key pathological mechanisms of PVD recognized in Western medicine.Accordingly,this paper conducts research from the following three aspects:First,it clarifies that immune dysregulation,metabolic disorders,and genetic susceptibility constitute the core pathological mechanisms of PVD in Western medicine.Typical pathological manifestations include progressive vascular endothelial injury,lipid deposition,and plaque formation,ultimately leading to multi-organ damage and dysfunction.PVD activates pathways such as the NOD-like receptor thermal protein domain-associated protein 3(NLRP3)inflammasome,triggering immune dysregulation;it also induces disorders of mitochondrial energy metabolism,water-salt metabolism,and hormonal metabolism,synergizing with genetic susceptibility factors(e.g.,apolipoprotein E gene)to accelerate vascular homeostasis imbalance.Second,this study analyzes the intrinsic relationship between the TCM theory of"kidney deficiency"and the"immune-metabolic-genetic"axis,revealing the theoretical basis for kidney tonification in intervening PVD.The kidney stores essence,governs bones,and produces marrow,which is related to the generation and differentiation of immune cells.It regulates Qi transformation and governs water,overseeing material and energy metabolism.The kidney is the root of congenital essence and governs reproduction,closely related to genetic mechanisms.Third,by integrating modern clinical research,this study elaborates on the unique advantages and clinical value of kidney tonification in targeting the"immune-metabolic-genetic"axis of heart,brain,and kidney organs.Traditional kidney-tonifying formulas and their active ingredients improve immune-inflammatory responses,enhance material and energy metabolism homeostasis,and modulate epigenetic pathways through multiple pathways,targeting various pathways to intervene in PVD.This study systematically elucidates the scientific connotation of kidney tonification in treating PVD,providing theoretical support and practical guidance for integrated TCM-Western medicine approaches and contributing to innovation and improvement in diagnostic and treatment strategies for PVD.