柴胡加龙骨牡蛎汤加味治疗慢性萎缩性胃炎临床研究OA

Objective:To observe the clinical efficacy of Supplemented Bupleurum Decoction Plus Dragon Bones and Oyster Shell on chronic atrophic gastritis(CAG).Methods:A total of 120 CAG patients were divided into the study group and the control group using the random number table method,with 60 cases in each group.The control group received Omeprazole Enteric-coated Capsules and Col-loidal Bismuth Pectin Capsules for oral administration.The study group received Supplemented Bupleurum Decoction Plus Dragon Bones and Oyster Shell in addition to the treatment given to the control group.The clinical efficacy,and changes in TCM syndrome scores,ser-um gastric function indicators[including Gastrin-17(G-17),Pepsinogen Ⅰ(PG Ⅰ),Pepsinogen Ⅱ(PG Ⅱ),Endothelin-1(ET-1)],levels of inflammatory factors[including tumor necrosis factor-α(TNF-α),interleukin-6(IL-6),and C-reactive protein(CRP)],and histopathological scores of gastric mucosa before and after treatment were compared between the two groups.Results:After treatment,scores for epigastric burning,epigastric fullness and stuffiness,poor appetite,fatigue and lassitude,bitter taste and halitosis,as well as the total scores,were lower than those before treatment within each group.Furthermore,these scores were lower in the study group than in the control group,with all differences being statistically significant(P<0.05).The effective rate was91.67%in the study group and 78.33%in the control group,showing a statistically significant difference(P<0.05).After treatment,the levels of G-17,PG Ⅰ,and PG Ⅱ in the study group were(385.43±31.02)ng·L-1,(122.15±12.09)ng·L-1,and(25.62±3.26)ng·L-1,respectively,which were higher than those before treatment in the same group and higher than those in the control group after treat-ment(P<0.05).The levels of ET-1,CRP,IL-6,and TNF-αin the study group after treatment were(65.52±7.53)ng·L-1,which were lower than those before treatment in the same group and lower than those in the control group after treatment(P<0.05).All path-ological scores of gastric mucosal tissues in the two groups after treatment were lower than those before treatment within each group,and the scores in the study group were lower than those in the control group(P<0.05).Conclusion:Supplemented Bupleurum Decoction Plus Dragon Bones and Oyster Shell is effective in treating CAG,which can significantly improve clinical symptoms,gastric function in-dicators,inflammatory response,and the pathological state of gastric mucosa of the patients.