Advances of coumarins in Angelica gigas Nakai with anti-prostatic carcinoma activityOA
Prostatic carcinoma(PCa)has become one of the most common cancers among men worldwide,with both incidence and mortality rates steadily rising.Although current treatments are effective in the early stages of PCa,many cases eventually progress to castration-resistant prostate cancer(CRPC),and led to treatment failure.To develop new therapeutic strategies to ameliorate the survival of PCa patients then has pressed the need on medicinal researchers.Of traditional Chinese medicinal herbs,Angelica gigas Naka(AGN),and its major pyranocoumarins were broadly reported on the effect of anti-PCa.However,existing reviews mainly focus on decursin(D),decursinol angelate(DA),and decursinol(DOH),without fully exploring other coumarins in AGN.Moreover,most reviews discuss general anticancer effects,with limited emphasis on PCa specifically.This review made a comprehensive summary of the coumarin components of AGN,and depicted the anti-PCa effects and mechanisms,giving a solid research support for drug discovery and development.This review also featured pharmacokinetic advantages and therapeutic potential of DOH,in order to suggest possibilities to overcome the in vivo transformation limitations of D and DA,and shed light on CRPC treatment.We also recommend future studies focus on more in vivo evidence,safety and toxicity evaluation,and clinical validation in humans.
Wei Wu;Yu-Qi Liang;Wei-Ling Pu;Cui-Ling Feng;Kai-Long Li;Hui-Yong Zhang
School of Life Sciences,Zhuhai College of Science and Technology,Zhuhai 519041,China School of Basic Medical Sciences,Peking University Health Science Center,Beijing 100191,ChinaSchool of Life Sciences,Zhuhai College of Science and Technology,Zhuhai 519041,ChinaState Key Laboratory of Component-based Chinese Medicine,Tianjin University of Traditional Chinese Medicine,Tianjin 301617,ChinaDepartment of Traditional Chinese Medicine,Peking University People’s Hospital,Beijing 100044,ChinaSchool of Basic Medical Sciences,Peking University Health Science Center,Beijing 100191,ChinaDepartment of Traditional Chinese Medicine,The Forth Affiliated Hospital of China Medical University,Shenyang 110084,China
医药卫生
Angelica gigas Nakaicoumarinsprostatic carcinomaherb medicine
《Traditional Medicine Research》 2026 (4)
P.50-63,14
supported by the Natural Science Foundation of Guangdong Province(grant number 2021A1515011485)the Traditional Chinese Medicine Multidisciplinary Innovation Team Program of Liaoning Province(grant number LNZYYCXTD-JCCX-002)the Key Laboratory foundation of Ministry of Education for TCM Viscera State Theory and Applications of Liaoning University of Traditional Chinese Medicine(grant number.zyzx1807)“Three levels”Talent Construction Projects in Zhuhai College of Science and Technology.
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