Intelligent integration and advancement of multi-organ-on-a-chipOA
Multi-organ-on-a-chip(MOOC)technology represents a pivotal direction in the organ-on-a-chip field,seeking to emulate the complex interactions of multiple human organs in vitro through microfluidic systems.This technology overcomes the limitations of traditional single-organ models,providing a novel platform for investigating complex disease mechanisms and evaluating drug efficacy and toxicity.Although it demonstrates broad application prospects,its development still faces critical bottlenecks,including inadequate physiological coupling between organs,short functional maintenance durations,and limited real-time monitoring capabilities.Contemporary research is advancing along three key directions,including functional coupling,sensor integration,and full-process automation systems,to propel the technology toward enhanced levels of physiological relevance and predictive accuracy.
Chen-Xi Song;Lu Huang
School of Biomedical Engineering,Shenzhen Campus of Sun Yat-sen University,Shenzhen 518107,ChinaSchool of Biomedical Engineering,Shenzhen Campus of Sun Yat-sen University,Shenzhen 518107,China Key Laboratory of Sensing Technology and Biomedical Instruments of Guangdong Province,School of Biomedical Engineering,Sun Yat-sen University,Guangzhou 510275,China
医药卫生
investigating complex disease mechanismsemulate complex interactions multiple human organs vitrosensor integrationintelligent integrationpredictive accuracyphysiological couplingmulti organ chipmicrofluidic systemsthis
《Biomedical Engineering Communications》 2026 (1)
P.1-3,3
supported by the Shenzhen Medical Research Fund(Grant No.A2303049)Guangdong Basic and Applied Basic Research(Grant No.2023A1515010647)National Natural Science Foundation of China(Grant No.22004135)Shenzhen Science and Technology Program(Grant No.RCBS20210706092409020,GXWD20201231165807008,20200824162253002).
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