磁共振3D-T1WI及扩散张量成像在评估意识障碍中的研究进展OA
Research Progress of Magnetic Resonance 3D-T1WI and Diffusion Tensor Imaging in the Assessment of Disorders of Consciousness
意识障碍(Disorders of Consciousness,DOC)是一类严重的神经系统疾病状态,准确评估DOC的程度及相关病理生理机制对于患者的治疗及预后至关重要.传统的影像学检查,如常规磁共振成像或计算机断层扫描,在评估DOC患者的微观结构改变和脑功能连接方面存在局限性.磁共振3D-T1加权成像(3D-T1 Weighted Imaging,3D-T1WI)和扩散张量成像(Diffusion Tensor Imaging,DTI)可以客观反映异常的大脑结构及功能变化,为探究DOC的病理生理机制提供详细的影像学依据,在DOC评估领域具有独特的优势.本文综述了3D-T1WI和DTI在DOC评估中的最新应用,总结了DOC患者脑结构和功能变化及其病理生理机制,以期为DOC的诊断、预后及治疗提供参考.
Disorders of consciousness(DOC)are a group of severe neurological disorders.Accurate assessment of the severity of DOC and related pathophysiological mechanisms is crucial for patients'treatment and prognosis.Traditional imaging examinations,such as conventional magnetic resonance imaging or computed tomography,have limitations in evaluating microstructural changes and brain functional connectivity in DOC patients.Magnetic resonance 3D-T1 weighted imaging(3D-T1WI)and diffusion tensor imaging(DTI)can objectively reflect abnormal brain structural and functional changes,provide detailed imaging evidence for exploring the pathophysiological mechanisms of DOC,and possess unique advantages in the field of DOC assessment.This paper reviewed the latest applications of 3D-T1WI and DTI in DOC assessment,summarized the changes in brain structure and function as well as their pathophysiological mechanisms in DOC patients,and aiming to provide a reference for the diagnosis,prognosis,and treatment of DOC.
吴莹;徐茹;钱丽霞
山西医科大学 医学影像学院,山西 太原 030001山西医科大学 医学影像学院,山西 太原 030001山西白求恩医院/山西医学科学院 放射科,山西 太原 030032
医药卫生
意识障碍(DOC)磁共振成像(MRI)扩散张量成像(DTI)3D-T1加权成像(3D-T1WI)脑损伤
disorders of consciousness(DOC)magnetic resonance imaging(MRI)diffusion tensor imaging(DTI)3D-T1 weighted imaging(3D-T1WI)brain injury
《中国医疗设备》 2025 (11)
175-179,192,6
山西省基础研究计划(202103021224344).
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