合成MRI、双指数及拉伸指数模型在鉴别前列腺癌与良性增生的应用OA

Objective To compare the value of synthetic magnetic resonance imaging(SyMRI),bi-exponential model,and stretched exponential model(SEM)with mono-exponential model apparent diffusion coefficient(ADC)in differentiating prostate cancer(PCa)from benign prostatic hyperplasia(BPH).Methods This study enrolled 72 patients who underwent prostate MRI at Fujian Medical University Union Hospital between November 2021 and April 2022,including 40 cases of PCa and 32 cases of BPH.The differences of mono-exponential ADC values,T1,T2 and PD values of SyMRI,D,D* and f values of bi-exponential,DDC and α values of SEM were compared between PCa and BPH group,and the diagnostic efficacy of each parameter was analyzed.Multiparametric models,including SyMRI(T1+T2+PD),bi-exponential(D+D*+f),and SEM(DDC+α)were constructed and compared with mono-exponential ADC for diagnostic efficacy.Results ADC,T2,T1,D,D*,f and DDC values were lower in the PCa group than in the BPH group.However PD and α were not statistically different(P>0.05).The highest diagnostic efficacy was found in T2 of SyMRI(AUC=0.956),D of bi-exponential(AUC=0.959)and DDC of SEM(AUC=0.971).The diagnostic performance of SyMRI model(T1+T2+PD)(AUC=0.973)and bi-exponential model(D+D*+f)(AUC=0.998)was better than that of the mono-exponential model(AUC=0.900),both of which were positive improvements,with statistically significant differences(P<0.05).However,the diagnostic efficacy of SEM(DDC+α)(AUC=0.920)was not significantly improved compared with the mono-exponential model.Conclusion T2,T1,D,D*,f,and DDC can effectively identify PCa and BPH.The diagnostic efficacy of the multi-parameter models of SyMRI and bi-exponential were superior to that of mono-exponential ADC,which can be promoted for clinical use.