Distributions of parvalbumin,calbindin-D28k,and calretinin in the cerebrum of Chinese tree shrews(Tupaia belangeri chinensis):A high-resolution neuroanatomical resourceOACSCDCSTPCD
The Chinese tree shrew has gained prominence as a model organism due to its phylogenetic proximity to primates,offering distinct advantages over traditional rodent models in biomedical research.However,the neuroanatomy of this species remains insufficiently defined,limiting its utility in neurophysiological and neuropathological studies.In this study,immunofluorescence microscopy was employed to comprehensively map the distribution of three calciumbinding proteins,parvalbumin,calbindin D-28k,and calretinin,across the tree shrew cerebrum.Serial brain sections in sagittal,coronal,and horizontal planes from 12 individuals generated a dataset of 3638 cellular-resolution images.This dataset,accessible via Science Data Bank(https://doi.org/10.57760/sciencedb.23471),provides detailed region-and laminar-selective distributions of calcium-binding proteins valuable for the cyto-and chemoarchitectural characterization of the tree shrew cerebrum.This resource will not only advance our understanding of brain organization and facilitate basic and translational neuroscience research in tree shrews but also enhance comparative and evolutionary analyses across species.
Rong Zhang;Jia-Li Long;Yi-Fan Ye;Hao-Yun Ye;Xiao-Nan Zhao;Xing Cai;Li Lu
State Key Laboratory of Genetic Evolution&Animal Models,and Key Laboratory of Animal Models&Human Disease Mechanisms of Yunnan Province,Kunming Institute of Zoology,Chinese Academy of Sciences,Kunming,Yunnan 650201,China National Resource Center for Non-Human Primates,Kunming Primate Research Center,and National Research Facility for Phenotypic&Genetic Analysis of Model Animals(Primate Facility),Kunming Institute of Zoology,Chinese Academy of Sciences,Kunming,Yunnan 650107,ChinaState Key Laboratory of Genetic Evolution&Animal Models,and Key Laboratory of Animal Models&Human Disease Mechanisms of Yunnan Province,Kunming Institute of Zoology,Chinese Academy of Sciences,Kunming,Yunnan 650201,China Kunming College of Life Science,University of Chinese Academy of Sciences,Kunming,Yunnan 650204,ChinaState Key Laboratory of Genetic Evolution&Animal Models,and Key Laboratory of Animal Models&Human Disease Mechanisms of Yunnan Province,Kunming Institute of Zoology,Chinese Academy of Sciences,Kunming,Yunnan 650201,China Kunming College of Life Science,University of Chinese Academy of Sciences,Kunming,Yunnan 650204,ChinaState Key Laboratory of Genetic Evolution&Animal Models,and Key Laboratory of Animal Models&Human Disease Mechanisms of Yunnan Province,Kunming Institute of Zoology,Chinese Academy of Sciences,Kunming,Yunnan 650201,ChinaState Key Laboratory of Genetic Evolution&Animal Models,and Key Laboratory of Animal Models&Human Disease Mechanisms of Yunnan Province,Kunming Institute of Zoology,Chinese Academy of Sciences,Kunming,Yunnan 650201,ChinaState Key Laboratory of Genetic Evolution&Animal Models,and Key Laboratory of Animal Models&Human Disease Mechanisms of Yunnan Province,Kunming Institute of Zoology,Chinese Academy of Sciences,Kunming,Yunnan 650201,China National Resource Center for Non-Human Primates,Kunming Primate Research Center,and National Research Facility for Phenotypic&Genetic Analysis of Model Animals(Primate Facility),Kunming Institute of Zoology,Chinese Academy of Sciences,Kunming,Yunnan 650107,ChinaState Key Laboratory of Genetic Evolution&Animal Models,and Key Laboratory of Animal Models&Human Disease Mechanisms of Yunnan Province,Kunming Institute of Zoology,Chinese Academy of Sciences,Kunming,Yunnan 650201,China National Resource Center for Non-Human Primates,Kunming Primate Research Center,and National Research Facility for Phenotypic&Genetic Analysis of Model Animals(Primate Facility),Kunming Institute of Zoology,Chinese Academy of Sciences,Kunming,Yunnan 650107,China
医药卫生
Tree shrewDistributionParvalbuminCalbindinCalretininResource
《Zoological Research》 2025 (4)
P.893-911,19
supported by the Science and Technology Innovation(STI)2030-Major Projects(2022ZD0205000 to L.L.)CAS“Light of West China”Program(xbzg-zdsys-202404 to L.L.)Yunnan Revitalization Talent Support Program Yunling Scholar Project(to L.L.)Yunnan Fundamental Research Projects(202305AH340006,202301AS070060 to L.L.,202401AT070206 to X.C.)。
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