Recent advances in shikonin nanoformulations for managing inflammation-related diseaseOA
Shikonin,a naphthoquinone compound derived from the root of Lithospermum erythrorhizon,has been extensively studied for its antibacterial,antioxidant,and anti-inflammatory properties.Increasing evidence highlights its potential in treating inflammation-related diseases.However,its clinical application is hindered by challenges such as poor water solubility,rapid metabolism in vivo,and other limitations.Recent advancements have demonstrated that encapsulating shikonin within nanocarriers can significantly enhance its water solubility and pharmacokinetic profile.Building on this,this perspective paper outlines the current landscape of inflammation treatment,explores the anti-inflammatory mechanisms of shikonin,reviews the latest progress in shikonin-based nanomaterials for anti-inflammatory applications,and discusses the challenges and future directions for the clinical translation of shikonin nanoformulations.
Ting-Ting Zuo;Jun-Jie Zhang;Derya bal Altuntaş;Dong-Liang Yang;Chao Zhang
College of Biological Sciences and Technology,Yili Normal University,Yining 835000,ChinaSchool of Fundamental Sciences,Bengbu Medical University,Bengbu 233030,ChinaFaculty of Engineering and Architecture,Department of Bioengineering,Recep Tayyip Erdogan University,Rize 53100,TurkeyState Key Laboratory of Flexible Electronics(LoFE)&Institute of Advanced Materials(IAM),School of Physical and Mathematical Sciences,Nanjing Tech University,Nanjing 211816,ChinaDepartment of Neurosurgery,Zhujiang Hospital,Southern Medical University,Guangzhou 510282,China
医药卫生
shikoninnanomedicineinflammation-related diseases
《Traditional Medicine Research》 2026 (2)
P.69-75,7
supported by the National Natural Science Foundation of China(82373393),Xinjiang Uygur Autonomous Region“Tianchi Yingcai”Project(2023TCYCQNBS02)Xinjiang Uygur Autonomous Region Colleges and Universities Basic Research Operating Expenses Scientific Research Project(XJEDU2022P106).
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