386例胃癌患者错配修复蛋白表达与临床病理特征及预后的相关性分析OA
Correlation analysis of mismatch repair protein expression with clinicopathological features and prognosis in 386 gastric cancer patients
目的 探讨胃癌患者中错配修复(MMR)蛋白表达及其缺失(dMMR)与临床病理特征、生存预后的关系.方法 收集 2018 年 1-12 月潍坊市人民医院 386 例胃癌根治术患者组织样本,制备组织芯片.经免疫组织化学检测MutL同源物 1(MLH1),减数分裂后分离增加蛋白 2(PMS2)、MutS同源物 2(MSH2)及MutS同源物6(MSH6)等MMR蛋白表达,分析其与临床特征相关性,绘制Kaplan-Meier生存曲线,并进行Cox回归分析.结果 43 例(11.14%)发生dMMR,MLH1 与PMS2 的缺失模式高度一致(φ=0.623);dMMR与患者年龄、性别、肿瘤位置、直径以及N分期显著相关,dMMR组患者总体生存率显著高于错配修复功能完整(pMMR)组(log-rank P=0.0125);Cox回归分析显示dMMR是预测胃癌患者生存情况的独立预后因子.结论 dMMR与胃癌多项临床病理特征相关,dMMR患者预后较好,可作为胃癌生存情况的独立预后因子.
Objective To investigate the relationship between mismatch repair(MMR)protein expression,deficient mismatch repair(dMMR),and clinicopathological characteristics as well as survival prognosis in gastric cancer patients.Methods Tissue samples from 386 patients who underwent radical gastrectomy for gastric cancer at Weifang People's Hospital between January and December 2018 were collected,and tissue microarrays were constructed.Immunohistochemistry(IHC)was used to detect the expression of MMR proteins,including MutL homolog 1(MLH1),post meiotic isolated increasing protein 2(PMS2),MutS homolog 2(MSH2),and MutS homolog 6(MSH6).The correlation between MMR protein expression and clinical characteristics was analyzed.Kaplan-Meier survival curves were plotted,and Cox regression analysis was performed.Results dMMR was observed in 43 cases(11.14%).The loss patterns of MLH1 and PMS2 demonstrated high concordance(φ=0.623).dMMR status was significantly associated with patient age,sex,tumor location,tumor diameter,and N stage.The overall survival rate was significantly higher in the dMMR group compared to the proficient MMR(pMMR)group(log-rank P=0.0125).Multivariate Cox regression analysis identified dMMR as an independent prognostic factor for predicting survival in gastric cancer patients.Conclusion dMMR is associated with several clinicopathological features in gastric cancer.Patients with dMMR exhibit a more favorable prognosis,and dMMR status serves as an independent prognostic factor for survival in gastric cancer.
刘德美;徐国栋;刘淑真;王慧;姜杰;李秀凤
山东省潍坊市人民医院精准病理诊断中心,山东 潍坊 261041山东省潍坊市人民医院精准病理诊断中心,山东 潍坊 261041山东省潍坊市人民医院肿瘤内科,山东 潍坊 261041山东省潍坊市人民医院精准病理诊断中心,山东 潍坊 261041山东省潍坊市人民医院精准病理诊断中心,山东 潍坊 261041山东省潍坊市人民医院精准病理诊断中心,山东 潍坊 261041
医药卫生
胃癌错配修复蛋白病理特征预后
Gastric cancerMismatch repair proteinClinicopathological characteristicsPrognosis
《中国医药科学》 2025 (16)
22-27,6
山东省自然科学基金面上项目(ZR2021MH261)山东省潍坊市卫生健康委科研项目(WFWSJK-2021-069).
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