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有创及无创血气检测技术的研究进展OA

Research Progress on Invasive and Non-Invasive Blood Gas Detection Technologies

中文摘要英文摘要

血气分析在医学上应用广泛,其发展历史有200多年,目前临床常用的血气分析方法主要为有创血气分析检测技术,尽管发展技术已很成熟,但临床使用中仍有诸多问题,如有创导致的感染、出血、监测不连续等.为弥补有创技术的不足,无创血气监测技术应运而生并不断发展.传统无创技术如脉搏血氧仪、CO2描记图等存在精度局限,而新型技术中,气相色谱-质谱法、可调谐半导体激光吸收光谱技术、光声光谱技术等逐渐应用.本文对血气分析的发展历史和检测技术进行了阐述,探讨了无创血气分析技术的发展,尤其关注基于光学的腔衰荡激光光谱技术在无创血气分析监测技术中的应用,并展望了未来无创血气分析技术的发展方向,以期为相关设备研发提供参考.

Blood gas analysis is widely applied in medicine,with a development history of over 200 years.Currently,the commonly used clinical method for blood gas analysis is invasive blood gas detection technology.Although this technology has been well-developed,it still presents numerous issues in clinical practice,such as infection,bleeding,and discontinuous monitoring caused by invasiveness.To address the limitations of invasive techniques,non-invasive blood gas monitoring technology has emerged and continued to evolve.Traditional non-invasive technologies,such as pulse oximeters and capnogram,have limitations in accuracy.Among new technologies,gas chromatography-mass spectrometry,tunable diode laser absorption spectroscopy,and photoacoustic spectroscopy have been gradually applied.This paper elaborated on the development history and detection technologies of blood gas analysis,explored the development of non-invasive blood gas analysis technology,with a particular focus on the application of cavity ring-down spectroscopy based on optics in non-invasive blood gas analysis monitoring technology,and prospected the future development direction of non-invasive blood gas analysis technology,aiming to provide references for the research and development of related equipment.

张荣荣;明可欣;王冲;张蕾

中国科学技术大学附属第一医院/安徽省立医院 重症医学科,安徽 合肥 230001中国科学技术大学 地球和空间科学学院,安徽 合肥 230026中国科学技术大学 地球和空间科学学院,安徽 合肥 230026中国科学技术大学附属第一医院/安徽省立医院 重症医学科,安徽 合肥 230001

医药卫生

有创血气分析脉搏血氧仪血气发展史腔衰荡激光光谱技术(CRDS)气相色谱-质谱法(GC-MS)

invasive blood gas analysisnon-invasive blood gas analysispulse oximetercavity ring-down spectroscopy(CRDS)gas chromatography-mass spectrometry(GC-MS)

《中国医疗设备》 2025 (9)

139-148,10

国家重点研发计划(2023YFC308110).

10.3969/j.issn.1674-1633.20241667

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