Argopecten属海湾扇贝和紫扇贝的寿命调控机制OA北大核心

Marine bivalves hold significant economic,ecological,and sustainable developmental value in global fisheries and aquaculture.American scholars have reported that marine bivalves are ideal models for analyzing the regulatory mechanisms of natural aging and longevity.Bay scallops(Argopecten irradians)(<14 months)and Pe-ruvian scallops(A.purpuratus)(7-10 a)are not completely reproductively isolated;however,the genetic variations in their genomes resulting from long-term adaptation to different environments have led to distinct lifespans,providing unique materials for investigating lifespan evolution mechanisms.The insulin/insulin-like growth factor signaling(IIS)pathway is a key pathway involved in various life processes,including growth,metabolism,repro-duction,and lifespan.It is the first aging regulatory signaling pathway discovered and widely validated.This study reviews the potential mechanisms influencing lifespan determination through the IIS pathway in the two species of Argopecten from genetic and environmental perspectives.Genetic variation results in differences in protease activ-ity and phosphorylation levels of core genes within the IIS pathway.Under environmental stress,variations in IIS pathway regulation,antioxidant and DNA repair responses,and metabolic regulation may contribute to the differ-ences in lifespan among Argopecten scallops.This review provides new insights into evaluating lifespan evolution mechanisms in marine bivalves,further enhancing the theoretical understanding of aging and longevity mechanisms.Additionally,it offers theoretical foundations and biological markers for breeding long-lived,larger scallops.