On the evolution of microgliaOACSCDCSTPCD
Over the last three decades,microglia have been recognized as essential components of central nervous system(CNS)development,homeostasis,immune surveillance,and neurodegenerative pathogenesis(Lin&Wang,2024;Prinz et al.,2019).Historically,microglia were regarded as exclusive to the CNS,based on the absence of cells bearing microglial morphology,transcriptional identity,and ontogeny in tissues outside the CNS in standard mouse and rat models.
Zhisheng Wu;Rongfeng Cui;Hanjie Li
Key Laboratory of Quantitative Synthetic Biology,Shenzhen Institute of Synthetic Biology,Shenzhen Institutes of Advanced Technology,Chinese Academy of Sciences,Shenzhen,Guangdong 518055,ChinaSchool of Ecology&State Key Laboratory of Biocontrol,Sun Yat-sen University,Shenzhen,Guangdong 518107,China Southern Marine Science and Engineering Guangdong Laboratory,Zhuhai,Guangdong 519082,ChinaKey Laboratory of Quantitative Synthetic Biology,Shenzhen Institute of Synthetic Biology,Shenzhen Institutes of Advanced Technology,Chinese Academy of Sciences,Shenzhen,Guangdong 518055,China Shenzhen University of Advanced Technology,Shenzhen,Guangdong 518055,China
医药卫生
homeostasisdevelopmentmouse rat modelscentral nervous system cns developmenthomeostasisimmuneneurodegenerative pathogenesisneurodegenerative pathogenesis lin wang prinzmicrogliaimmune surveillance
《Zoological Research》 2025 (3)
P.483-484,2
supported by the National Natural Science Foundation of China(32425024)Shenzhen Medical Research Fund(B2302006)。
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