Clinical potential of undercarboxylated osteocalcin in metabolic and neurodegenerative diseases:From biomarker to therapeutic targetOA
Osteocalcin(OCN),a non-collagenous protein synthesized by osteoblasts,is integral to bone mineralization and demonstrates significant effects on metabolic and neurological functions.Its undercarboxylated form,Glu-OCN,has emerged as a key regulator of glucose metabolism in diabetes,bone density in osteoporosis(OP),and lipid metabolism in conditions such as nonalcoholic fatty liver disease(NAFLD).Additionally,Glu-OCN is implicated in neurodegenerative and cardiovascular diseases through its roles in neurotransmitter synthesis and vascular calcification,respectively.This review examines the essential functions of Glu-OCN in the management of metabolic and neurodegenerative disorders,emphasizing its significance as both a diagnostic biomarker and therapeutic target.While findings to date are promising,most studies remain observational.Advanced detection methodologies and extensive longitudinal studies are urgently needed to elucidate the mechanisms and clinical applications of Glu-OCN.Advancements in this area could facilitate the integration of Glu-OCN into personalized medicine approaches,improving early diagnosis,risk assessment,and treatment monitoring.
Ying-ying Ding;Yu-ying Yang;Li-hao Sun;Jian-min Liu;Bei Tao
Department of Endocrine and Metabolic Diseases,Shanghai Institute of Endocrine and Metabolic Diseases,Ruijin Hospital,Shanghai Jiao Tong University School of Medicine,Shanghai 200025,China Shanghai National Clinical Research Center for Metabolic Diseases,Key Laboratory for Endocrine and Metabolic Diseases of the National Health Commission of China,Shanghai National Center for Translational Medicine,Ruijin Hospital,Shanghai Jiao Tong University School of Medicine,Shanghai 200025,ChinaDepartment of Endocrine and Metabolic Diseases,Shanghai Institute of Endocrine and Metabolic Diseases,Ruijin Hospital,Shanghai Jiao Tong University School of Medicine,Shanghai 200025,China Shanghai National Clinical Research Center for Metabolic Diseases,Key Laboratory for Endocrine and Metabolic Diseases of the National Health Commission of China,Shanghai National Center for Translational Medicine,Ruijin Hospital,Shanghai Jiao Tong University School of Medicine,Shanghai 200025,ChinaDepartment of Endocrine and Metabolic Diseases,Shanghai Institute of Endocrine and Metabolic Diseases,Ruijin Hospital,Shanghai Jiao Tong University School of Medicine,Shanghai 200025,China Shanghai National Clinical Research Center for Metabolic Diseases,Key Laboratory for Endocrine and Metabolic Diseases of the National Health Commission of China,Shanghai National Center for Translational Medicine,Ruijin Hospital,Shanghai Jiao Tong University School of Medicine,Shanghai 200025,ChinaDepartment of Endocrine and Metabolic Diseases,Shanghai Institute of Endocrine and Metabolic Diseases,Ruijin Hospital,Shanghai Jiao Tong University School of Medicine,Shanghai 200025,China Shanghai National Clinical Research Center for Metabolic Diseases,Key Laboratory for Endocrine and Metabolic Diseases of the National Health Commission of China,Shanghai National Center for Translational Medicine,Ruijin Hospital,Shanghai Jiao Tong University School of Medicine,Shanghai 200025,ChinaDepartment of Endocrine and Metabolic Diseases,Shanghai Institute of Endocrine and Metabolic Diseases,Ruijin Hospital,Shanghai Jiao Tong University School of Medicine,Shanghai 200025,China Shanghai National Clinical Research Center for Metabolic Diseases,Key Laboratory for Endocrine and Metabolic Diseases of the National Health Commission of China,Shanghai National Center for Translational Medicine,Ruijin Hospital,Shanghai Jiao Tong University School of Medicine,Shanghai 200025,China
医药卫生
Osteocalcin(OCN)Nonalcoholic fatty liver disease(NAFLD)Diabetes mellitus(DM)Osteoporosis(OP)AtherosclerosisNeurodegenerative diseases(NDs)
《LabMed Discovery》 2025 (2)
P.57-66,10
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