基于网络药理学及分子对接探究百合抗乳腺癌的作用机制OA

Objective Predict the mechanism of action of lily in the treatment of breast cancer(BC)based on network pharmacology and molecular docking.Methods By combining target prediction technology with bioinformatics,the action targets of lily in the treatment of BC were predicted and functional and pathway enrichment analyses were conducted on them.Results Using the Traditional Chinese Medicine Systems Pharmacology Database and Analysis Platform(TCMSP),55 target genes of lilies were retrieved.A total of 2501 target genes closely related to BC were obtained in the Online Mendelian Inheritance in Man(OMIM)database and the GeneGards database.The protein-protein interaction network diagram between lilies and BC was plotted using Cytoscape software.The results show that the effective active components of lily affect biological processes including the positive regulation of apoptosis,the response of estradiol,intracellular steroid hormone receptor signaling pathways,etc.,and can also have multiple molecular functions such as enzyme binding,estrogen response element binding,RNA polymerase Ⅱ transcription factor activity,etc.And it affects the biological behavior of cancer cells by regulating related signaling pathways such as cancer pathways,chemocarcinogenic receptor activation,P53 and interleukin.Conclusion Lilies act on BC cells through multiple components,multiple targets and multiple pathways to achieve the effect of inhibiting BC.