无菌冷喷剂的研制及对初次献血献浆者疼痛干预的研究OA

Objective To observe the efficacy and safety of sterile cold spray in alleviating the pain of venipesis and the resulting anxiety and fear in first-time blood donors and plasma donors,in order to determine the safety and efficacy of sterile cold spray in reducing the pain related to venipesis in donors.Methods An open label,randomized controlled,and multicenter approach was adopted.Experiments on relieving pain with sterile cold spray and reducing the tension and fear of donors were conducted respectively in blood stations and plasma stations for 480 first-time voluntary blood donors and 2296 plasma donors.Blood donors were randomly divided into the observation group(n=240)and the control group(n=240),and plasma donors were randomly divided into the observation group(n=1146)and the control group(n=1150).Before venous puncture,the observation group was given sterile cold spray for pain intervention,and the sterile cold spray was sprayed at the puncture site for 4 to 10 seconds.The control group was operated as usual,and visual analogue scale and behavioral discipline assessment scale questionnaires were conducted for each group.Telephone follow-up survey was conducted on the willingness to donate blood for first-time blood donors;Telephone follow-up survey was conducted on the satisfaction of first-time plasma donors.Results There were no statistically significant differences among each group in terms of gender,educational background,age,height,weight and BMI(P>0.05).The pain score of the blood donor observation group was(2.75±1.85)points,and the anxiety score was(14.97±2.39)points.The pain score of the control group was(3.85±1.72)points,and the anxiety score was(16.76±2.62)points.The pain score of the plasma donor observation group was(2.67±1.87)points,and the anxiety score was(15.13±2.20)points.The pain score of the control group was(4.02±1.88)points and the anxiety score was(16.90±2.67)points.The differences between the two groups were statistically significant(P<0.001).In terms of the telephone follow-up on the willingness to donate blood,the proportion of the observation group willing to donate blood again was 72.1%,which was higher than 48.0%in the control group(P<0.001).For the telephone follow-up on the pain management satisfaction of plasma donors,the satisfaction rate of the observation group was 86.31%,which was higher than that of the control group(61.05%)(P<0.001).Conclusion The intervention of using sterile cold spray during venipesis for first-time blood donors or plasma donors can reduce their pain,relieve their anxiety,and is conducive to improving the willingness of donors to donate again.