Noradrenergic excitation of astrocytes supports cognitive reserveOA
The concept of the brain cognitive reserve is derived from the well-acknowledged notion that the degree of brain damage does not always match the severity of clinical symptoms and neurological/cognitive outcomes.It has been suggested that the size of the brain(brain reserve) and the extent of neural connections acquired through life(neural reserve) set a threshold beyond which noticeable impairments occur.In contrast,cognitive reserve refers to the brain''s ability to adapt and reo rganize stru cturally and functionally to resist damage and maintain function,including neural reserve and brain maintenance,resilience,and compensation(Verkhratsky and Zorec,2024).
Robert Zorec;Alexei Verkhratsky
Laboratory of Neuroendocrinology and Molecular Cell Physiology,Institute of Pathophysiology,University of Ljubljana,Ljubljana,Slovenia Celica Biomedical,Technology Park,Ljubljana,SloveniaLaboratory of Neuroendocrinology and Molecular Cell Physiology,Institute of Pathophysiology,University of Ljubljana,Ljubljana,Slovenia Celica Biomedical,Technology Park,Ljubljana,Slovenia Faculty of Biology,Medicine and Health,The University of Manchester,Manchester,UK Department of Neurosciences,University of the Basque Country,Leioa,Bizkaia,Spain and IKERBASQUE Basque Foundation for Science,Bilbao,Spain
医药卫生
astrocytesbrain reservecognitive reserveclinical symptomsnoradrenergic excitationneural reserveneural connectionsbrain cognitive reserve
《Neural Regeneration Research》 2026 (4)
P.1546-1547,2
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