Chromatin accessibility regulates axon regenerationOA
Central nervous system(CNS) axons fail to regenerate following brain or spinal cord injury(SCI),which typically leads to permanent neurological deficits.Peripheral nervous system axons,howeve r,can regenerate following injury.Understanding the mechanisms that underlie this difference is key to developing treatments for CNS neurological diseases and injuries characterized by axonal damage.To initiate repair after peripheral nerve injury,dorsal root ganglion(DRG) neurons mobilize a pro-regenerative gene expression program,which facilitates axon outgrowth.
Isa Samad;Brett J.Hilton
Department of Cellular and Physiological Sciences,Faculty of Medicine,University of British Columbia,Vancouver,BC,Canada International Collaboration on Repair Discoveries(ICORD),University of British Columbia,Vancouver,BC,Canada Djavad Mowafaghian Centre for Brain Health,University of British Columbia,Vancouver,BC,CanadaDepartment of Cellular and Physiological Sciences,Faculty of Medicine,University of British Columbia,Vancouver,BC,Canada International Collaboration on Repair Discoveries(ICORD),University of British Columbia,Vancouver,BC,Canada Djavad Mowafaghian Centre for Brain Health,University of British Columbia,Vancouver,BC,Canada
医药卫生
peripheral nerve injurydorsal root ganglion drgcentral nervous systemnervous systemdeveloping treatmentsspinal cord injurychromatin accessibilitycentral nervous system cnsspinal cord
《Neural Regeneration Research》 2026 (4)
P.1548-1549,2
supported by the Canada Foundation for Innovation (Project#44220)the Natural Sciences and Engineering Research Council of Canada (RGPIN-2024-03986)the Michael Smith Foundation for Health Research BCthe financial support of Health Canada,through the Canada Brain Research Fund,an innovative partnership between the Government of Canada (through Health Canada),Brain Canada Foundationthe Azrieli Foundationsupported by a Canadian Institutes of Health Research (CIHR) Canada Graduate Scholarship–Master’s Award。
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