mTORC1 and mTORC2 synergy in human neural development, disease, and regenerationOA
The mechanistic target of rapamycin(m TOR) is a serine/threonine kinase that plays a pivotal role in cellular growth, proliferation, survival, and metabolism. In the central nervous system(CNS), the mTOR pathway regulates diverse aspects of neural development and function. Genetic mutations within the m TOR pathway lead to severe neurodevelopmental disorders, collectively known as “mTORopathies”(Crino, 2020). Dysfunctions of m TOR, including both its hyperactivation and hypoactivation, have also been implicated in a wide spectrum of other neurodevelopmental and neurodegenerative conditions, highlighting its importance in CNS health.
Navroop K.Dhaliwal;Julien Muffat;Yun Li
Program in Developmental and Stem Cell Biology,The Hospital for Sick Children,Toronto,ON,CanadaProgram in Neurosciences and Mental Health,The Hospital for Sick Children,Toronto,ON,Canada Department of Molecular Genetics,University of Toronto,Toronto,ON,CanadaProgram in Developmental and Stem Cell Biology,The Hospital for Sick Children,Toronto,ON,Canada Department of Molecular Genetics,University of Toronto,Toronto,ON,Canada
医药卫生
m torneural developmentmtorccentral nervous system cnsmtorneurodevelopmental disordersneurodegenerative conditions
《Neural Regeneration Research》 2026 (4)
P.1552-1553,2
supported by grants from Simons Foundation (SFARI 479754),CIHR (PJT-180565)the Scottish Rite Charitable Foundation of Canada (to YL)funding from the Canada Research Chairs program。
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