Association between metabolically healthy obesity and risk of dementia:A systematic review and meta-analysisOA
Background:Some studies suggest that the metabolic alterations linked to obesity in humans may increase the likelihood of developing dementia.However,there are currently no existing meta-analyses exploring the possible occurrence of dementia in patients with metabolically healthy obesity(MHO).In the present study,we aimed to investigate a potential correlation between individuals with MHO and the likelihood of developing dementia. Method:Our research focused on searching three databases to locate perti-nent studies starting from January 10,2023.We used sensitivity analysis,the Egger's test,and a visual funnel plot to separately assess the reliability of the research results and publication bias.We conducted this study according to a pre-established protocol in the PROSPERO registry(CRD42023449459). Results:We incorporated three potential cohort investigations.Individuals with good metabolic health and obesity showed a decreased likelihood of developing dementia compared with those who were metabolically healthy but not obese(hazard ratio(HR)=0.79;95%confidence interval(CI)0.68-0.92).In contrast,individuals who were metabolically unhealthy and non-obese had an increased likelihood of developing dementia(HR=1.33;95%CI 1.25-1.42),whereas the population with metabolically unhealthy obesity did not exhibit a notable association with dementia onset(HR=1.06;95%CI 0.83-1.37). Conclusion:According to our meta-analysis,patients with MHO had a reduced likelihood of developing general dementia and Alzheimer disease.Maintaining a well-functioning metabolism can provide advantages in reducing the occurrence of dementia.
Yanyi Su;Yuecai Li;Rongqi Ding;Ziyi Zheng;Jiaqi Wang;Qixiang Fu;Jialin Deng;Hong Zhou
Department of Radiology,The First Affiliated Hospital,Hengyang Medical School,University of South China,Hengyang,China||Hengyang Medical School,University of South China,Hengyang,ChinaDepartment of Radiology,The First Affiliated Hospital,Hengyang Medical School,University of South China,Hengyang,China||Hengyang Medical School,University of South China,Hengyang,ChinaDepartment of Radiology,The First Affiliated Hospital,Hengyang Medical School,University of South China,Hengyang,China||Hengyang Medical School,University of South China,Hengyang,ChinaDepartment of Radiology,The First Affiliated Hospital,Hengyang Medical School,University of South China,Hengyang,China||Hengyang Medical School,University of South China,Hengyang,ChinaDepartment of Radiology,The First Affiliated Hospital,Hengyang Medical School,University of South China,Hengyang,China||Hengyang Medical School,University of South China,Hengyang,ChinaSchool of Pharmaceutical Science,University of South China,Hengyang,ChinaDepartment of Radiology,The First Affiliated Hospital,Hengyang Medical School,University of South China,Hengyang,China||Hengyang Medical School,University of South China,Hengyang,ChinaDepartment of Radiology,The First Affiliated Hospital,Hengyang Medical School,University of South China,Hengyang,China
Alzheimer diseasedementiametabolically healthy obesityoverall dementia
Alzheimer diseasedementiametabolically healthy obesityoverall dementia
《医学前沿（英文）》 2024 (2)
176-185,10
Health Commission Foundation of Hunan Province,Grant/Award Number:202209014295,202218014518Department of Education of Hunan Province,Grant/Award Number:HNJG-20230599Clinical Research 4310 Program of the First Affiliated Hospital of University of South China,Grant/Award Number:20224310NHYCG03
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