Review of metabolomics and microbiomics in esophageal cancer:From pathogenesis to prognosisOA
Esophageal cancer is a prevalent and aggressive malignancy associated with a poor prognosis.Metabolomics and microbiomics have emerged as promising approaches for investigating the tumor microenvironment and monitoring dynamic changes throughout the treatment process.These methodologies facilitate the direct observation of phenotypic alterations with high sensitivity,throughput,and adaptability across diverse sample types.Microbial genomic data play a crucial role in predicting the metabolic potential of microorganisms,whereas metabolomics offers direct evidence of active metabolic pathways under specific conditions.This review presents novel insights into the pathogenesis,diagnosis,and treatment of esophageal cancer through the application of metabolomics and microbiomics.Future advancements in the integration of multi-omics data are expected to further elucidate the metabolic mechanisms and pathophysiological processes underlying esophageal cancer,thereby laying a robust scientific foundation for early diagnosis,prognostic assessment,and personalized treatment strategies.
Yu-qin Cao;Yu-meng Cheng;Tian-cheng Li;Ya-jie Zhang;Cheng-qiang Li;He-cheng Li
Department of Thoracic Surgery,Ruijin Hospital,Shanghai Jiao Tong University School of Medicine,Shanghai 200025,ChinaDepartment of Thoracic Surgery,Ruijin Hospital,Shanghai Jiao Tong University School of Medicine,Shanghai 200025,ChinaDepartment of Thoracic Surgery,Ruijin Hospital,Shanghai Jiao Tong University School of Medicine,Shanghai 200025,ChinaDepartment of Thoracic Surgery,Ruijin Hospital,Shanghai Jiao Tong University School of Medicine,Shanghai 200025,ChinaDepartment of Thoracic Surgery,Ruijin Hospital,Shanghai Jiao Tong University School of Medicine,Shanghai 200025,ChinaDepartment of Thoracic Surgery,Ruijin Hospital,Shanghai Jiao Tong University School of Medicine,Shanghai 200025,China
医药卫生
Esophageal neoplasmsMetabolomicsMicrobiomeTumor microenvironment
《LabMed Discovery》 2025 (1)
P.27-37,11
supported by the National Natural Science Foundation of China(No.82072557)National Key Research and Development Program of China(No.2021YFC2500900)Fundamental Research Funds for the Central Universities(Grant No.YG2023QNB04)Shanghai Municipal Education Commission-Gaofeng Clinical Medicine Grant of China(No.20172005)support was provided by the Program of Shanghai Academic Research Leader from the Science and Technology Commission of Shanghai Municipality,China(No.20XD1402300)Novel Interdisciplinary Research Project from the Shanghai Municipal Health Commission,China(No.2022JC023)Interdisciplinary Program of Shanghai Jiao Tong University,China(No.YG2023ZD04)Clinical Research Project in Health Services of the Shanghai Municipal Health Commission of China(No.202240089).
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