SIRT6在呼吸系统疾病中的研究进展OA
Research progress of SIRT6 in respiratory system diseases
沉默信息调节蛋白6(SIRT6)作为烟酰胺腺嘌呤二核苷酸(NAD+)依赖的组蛋白,是沉默信息调节蛋白(sirtuins)家族的重要成员之一,属于Ⅲ类的组蛋白去乙酰化酶,其NAD+依赖的组蛋白去乙酰化酶、单二磷酸腺苷核糖基转移酶及去脂肪酰化酶等多种活性已被发现,并参与调节机体多种生命过程中,尤其在癌症、炎症、氧化应激、脱氧核糖核酸的损伤与修复、端粒维持、基因组稳定性等多种生理调节中发挥关键作用.本文综述SIRT6在部分呼吸系统疾病的相关研究进展.
As a nicotinamide adenine dinucleotide dependent histone,recombinant sirtuin 6(SIRT6)is an important member of the sirtuins family and belongs to Class Ⅲ histone deacetylase(HDAC).Its NAD+dependent histone deacetylase,adenosine diphosphate ribosyltransferase,and deacetylase activities have been discovered,and it plays a key role in regulating various life processes in the body,especially in cancer,inflammation,oxidative stress,deoxyribonucleic acid damage and repair,telomere maintenance,genome stability,and other physiological regulation.This article review the research progress of SIRT6 in some respiratory system diseases.
齐艳;孙云晖
佳木斯大学附属第一医院呼吸与危重症医学科,黑龙江佳木斯 154003佳木斯大学附属第一医院呼吸与危重症医学科,黑龙江佳木斯 154003
医药卫生
SIRT6NAD+组蛋白去乙酰化酶呼吸系统疾病研究进展
Silent mating-type information regulation-related protein type 6NAD+Histone deacetylaseRespiratory system diseasesResearch progress
《中国医药科学》 2025 (8)
22-25,4
黑龙江省卫生健康委员会科研课题(2020-323).
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