纳米技术在组织工程与再生医学中的全球研究趋势与热点分析OA
Global Research Trends and Hotspot Analysis of Nanotechnology in Tissue Engineering and Regenerative Medicine
目的 通过系统分析纳米技术在组织工程与再生医学领域的研究文献,揭示该领域的全球研究趋势与热点,为科研人员提供有价值的参考信息.方法 采用Web of Science数据库作为数据来源,设定关键词组合为"纳米""纳米科技""纳米材料"与"组织工程""再生医学",检索到2010-2024年发表的相关文献4499篇.通过数据预处理及BERTopic主题建模技术,对文献标题和摘要进行主题聚类和分析.结果 2010-2022年,纳米技术在组织工程与再生医学领域的论文发表量显著增加,但年度发文量存在波动,且自2022年起,论文发表数量有所减少.本研究成功识别出9个主要研究方向,包括纳米复合支架材料在骨组织工程中的应用、电纺技术在皮肤再生中的应用、纳米技术在水凝胶材料中的应用、钛及其氧化物在组织工程中的应用、细菌纤维素和壳聚糖在组织工程中的应用、纳米材料在药物递送中的应用、纳米技术在心脏组织工程中的应用、蚕丝蛋白纳米材料在组织工程中的应用及胶原蛋白基支架材料在肌腱和韧带修复中的应用.结论 总体而言,纳米技术在组织工程与再生医学的研究范围广泛,相关研究大多集中在生物材料的优化和功能化上.目前,这些研究已在骨科、皮肤科、心血管外科等多个临床方向取得了显著进展.未来,多功能材料、个性化材料、智能材料将有望成为该领域的研究重点.
Objective To systematically analyze the research literature on nanotechnology in the field of tissue engineering and regenerative medicine to reveal global research trends and hotspots in these areas,providing valuable reference information for researchers.Methods The Web of Science database was used as the data source,with the keyword combinations"nano""nanotechnology""nanomaterials"and"tissue engineering""regenerative medicine".A total of 4499 relevant papers published between 2010 and 2024 were retrieved.Data preprocessing and BERTopic topic modeling techniques were applied to perform topic clustering and analysis on the titles and abstracts of the papers.Results From 2010 to 2022,the number of papers published on nanotechnology in tissue engineering and regenerative medicine significantly increased.However,there were fluctuations in the annual publication volume,and since 2022,the number of papers published decreased.This study successfully identified 9 major research directions,including application of nanocomposite scaffold materials in bone tissue engineering;application of electrospinning technology in skin regeneration;application of nanotechnology in hydrogel materials;application of titanium and its oxides in tissue engineering;application of bacterial cellulose and chitosan in tissue engineering;application of nanomaterials in drug delivery;application of nanotechnology in cardiac tissue engineering;application of silk protein nanomaterials in tissue engineering;application of collagen-based scaffold materials in tendon and ligament repair.Conclusion Overall,nanotechnology has a broad research scope in tissue engineering and regenerative medicine,with most studies focusing on the optimization and functionalization of biomaterials.These studies have made significant progress in clinical fields such as orthopedics,dermatology,and cardiovascular surgery.In the future,multifunctional materials,personalized materials,and smart materials are expected to become the key research focus in this field.
王建波;欧阳昭连
中国医学科学院医学信息研究所,北京 100020中国医学科学院医学信息研究所,北京 100020
医药卫生
纳米技术组织工程与再生医学纳米材料电纺技术主题建模BERTopic热点分析
nanotechnologytissue engineering and regenerative medicinenanometer materialelectrospinning technologytopic modelingBERTopichotspot analysis
《中国医疗设备》 2025 (5)
24-33,41,11
中国医学科学院医学与健康科技创新工程"医学知识管理与智能化知识服务关键技术研究"(2021-I2M-1-056)国家自然科学基金(L1924064)深圳市卫生健康发展研究和数据管理中心"组织工程与再生医学专题报告项目"(sz20240119).
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