噻托溴铵联合多索茶碱治疗COPD的效果及对炎性因子的影响OA
Effect of Tiotropium Bromide Combined with Doxofylline in the Treatment of COPD and its Influence on Inflammatory Factors
目的:探讨慢性阻塞性肺疾病(COPD)患者采用噻托溴铵联合多索茶碱治疗的效果.方法:回顾性分析 2024年 1-12月滕州市中医医院完成治疗的 78例COPD患者,根据治疗方案不同将其分为对照组与研究组,各 39例.对照组采用多索茶碱治疗,研究组在对照组的基础上联合噻托溴铵治疗.两组均治疗30 d.比较两组治疗效果、肺功能指标、炎性因子水平、运动耐力、睡眠质量、生活质量.结果:研究组治疗有效率为 94.87%,较对照组 76.93%高,差异有统计学意义(P<0.05).治疗后,两组第一秒用力呼气容积(FEV1)、用力肺活量(FVC)、FEV1/FVC均较治疗前升高,且研究组均较对照组高,差异均有统计学意义(P<0.05).治疗后,两组白细胞介素-6、肿瘤坏死因子-α、C反应蛋白水平均较治疗前低,且研究组均较对照组低,差异均有统计学意义(P<0.05).治疗后,两组 6 min步行距离均长于治疗前,且研究组长于对照组,两组匹兹堡睡眠质量指数评分均低于治疗前,且研究组低于对照组,两组生活质量综合评定问卷-74评分均高于治疗前,且研究组高于对照组,差异均有统计学意义(P<0.05).结论:噻托溴铵联合多索茶碱治疗COPD患者可显著降低其机体炎症反应,有效改善肺功能,提升患者运动耐力、睡眠和生活质量,具有临床应用价值.
Objective:To explore the effect of Tiotropium Bromide combined with Doxofylline in the treatment of patients with chronic obstructive pulmonary disease(COPD).Methods:A retrospective analysis was conducted on 78 patients with COPD who finished treatment admitted to Traditional Chinese Medicine Hospital of Tengzhou City from January to December 2024.They were divided into a control group and a study group according to different treatment regimens,with 39 cases in each group.The control group was treated with Doxofylline,while the study group was treated with Tiotropium Bromide in combination with the control group.Both groups were treated for 30 days.The therapeutic effects,pulmonary function indicators,levels of inflammatory factors,exercise endurance,sleep quality and quality of life of the two groups were compared.Results:The effective rate of treatment in the study group was 94.87%,which was higher than 76.93%in the control group,and the difference was statistically significant(P<0.05).After treatment,the forced expiratory volume in one second(FEV1),forced vital capacity(FVC),and FEV1/FVC in both groups increased compared with those before treatment,and those in the study group were higher than those in the control group,the differences were statistically significant(P<0.05).After treatment,the levels of interleukin-6,tumor necrosis factor-α and C-reactive protein in both groups were lower than those before treatment,and the levels in the study group were lower than those in the control group,the differences were statistically significant(P<0.05).After treatment,the 6-Minute Walking Distance of both groups were longer than those before treatment,the study group were longer than the control group,the Pittsburgh Sleep Quality Index scores of both groups were lower than those before treatment,and the study group was lower than the control group,the score of the Comprehensive Quality of Life Questionnaire-74 of both groups was higher than those before treatment,and the study group was higher than the control group,the differences were all statistically significant(P<0.05).Conclusion:Tiotropium Bromide combined with Doxofylline in the treatment of COPD patients can significantly reduce the inflammatory response of their bodies,effectively improve lung function,enhance the exercise endurance,quality of life and sleep of patients,and has clinical application value.
张勉
山东省滕州市中医医院肺病科,山东 枣庄 277000
医药卫生
慢性阻塞性肺疾病噻托溴铵多索茶碱炎性因子生活质量
Chronic obstructive pulmonary diseaseTiotropium BromideDoxofyllineInflammatory factorsQuality of life
《中国伤残医学》 2025 (8)
45-48,4
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