鼠神经生长因子联合任务导向性康复训练对脑梗死偏瘫患者认知功能及肢体运动功能的影响OA
Effects of Mouse Nerve Growth Factor Combined with Task-Oriented Rehabilitation Training on Cognitive Function and Limb Motor Function in Patients with Hemiplegia after Cerebral Infarction
目的:探讨鼠神经生长因子联合任务导向性康复训练对脑梗死偏瘫患者认知功能及肢体运动功能的影响.方法:选取 2021年 9 月—2023年 11月沂源县人民医院收治的 64例脑梗死偏瘫患者为研究对象,以随机数字表法将其分为对照组和研究组,各 32例.两组均给予脑卒中二级预防治疗,对照组给予任务导向性康复训练,研究组在对照组基础上联合使用鼠神经生长因子,两组均连续治疗 8周.对比两组肢体运动功能、神经功能、认知功能及生活质量.结果:治疗后,两组上、下肢Fugl-Meyer运动功能量表、蒙特利尔认知评估量表、脑神经行为认知状态检查量表评分、Barthel指数均高于治疗前,且研究组均高于对照组,差异均有统计学意义(P<0.05).治疗后,两组美国国立卫生研究院卒中量表评分均低于治疗前,且研究组低于对照组,差异均有统计学意义(P<0.05).结论:鼠神经生长因子联合任务导向性康复训练应用于脑梗死偏瘫患者中效果良好,可有效促进患者神经功能恢复,改善患者认知功能和肢体运动功能,提升患者生活质量.
Objective:To investigate the effects of mouse nerve growth factor combined with task-oriented rehabilitation training on cognitive function and limb motor function in patients with hemiplegia after cerebral infarction.Methods:A total of 64 patients with hemiplegia after cerebral infarction admitted to Yiyuan County People's Hospital from September 2021 to November 2023 were selected as the study objects,and were divided into a control group and a study group by random number table method,with 32 cases in each group.Both groups were given secondary stroke prevention treatment,the control group was given task-oriented rehabilitation training,and the study group was treated with mouse nerve growth factor on the basis of the control group.Both groups were treated continuously for 8 weeks.The limb motor function,neurological function,cognitive function,and quality of life between the two groups were compared.Results:After treatment,the scores of upper adn lower extremity Fugl-Meyer Motor Function Scale,Montreal Cognitive Assessment Scale,Neurobehavioral Cognitive State Examination and Barthel Index in both group were higher than those before treatment,and the study group were higher than those of the control group,with statistical significance(P<0.05).After treatment,the scores of National Institutes of Health Stroke Scale of both group were lower than those before treatment,and the study group was lower than the control group,with statistical significance(P<0.05).Conclusion:The application of mouse nerve growth factor combined with task-oriented rehabilitation training in patients with hemiplegia after cerebral infarction has a good effect,which can effectively promote the recovery of neurological function,improve the cognitive function and limb motor function,and improve the quality of life of patients.
刘彦;张伟
山东省沂源县人民医院药学部,山东 淄博 255000山东省沂源县人民医院神经内一科,山东 淄博 255000
医药卫生
脑梗死偏瘫鼠神经生长因子任务导向性康复训练肢体运动功能认知功能
Cerebral infarctionHemiplegiaMouse nerve growth factorTask-Oriented rehabilitation trainingLimb motor functionCognitive function
《中国伤残医学》 2025 (2)
66-69,83,5
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